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AdipoGen Life Sciences
anti-BAFF (human), mAb (1-35-1)
400
CHF
CHF 400.00
In stock
AG-20B-0037-C100100 µgCHF 400.00
Figure 1: Detection of endogenous human BAFF using anti-BAFF (h) mAb (1-35-1)(AG-20B-0037).
Method: Neutrophils (CD15+) were stained with BAFF (h), mAb (1-35-1) (thick line) or an isotype control (thin line) at 10μg /ml each, revealed with a secondary antibody and then analyzed by flow cytometry.
Method: Neutrophils (CD15+) were stained with BAFF (h), mAb (1-35-1) (thick line) or an isotype control (thin line) at 10μg /ml each, revealed with a secondary antibody and then analyzed by flow cytometry.
| Product Details | |
|---|---|
| Synonyms | BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1-35-1 |
| Isotype | Rat IgG2aκ |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | HA-tagged human BAFF. |
| Application |
Flow Cytometry |
| Crossreactivity | Human |
| Specificity |
Recognizes human BAFF. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Product References
- Kinetics of free and ligand-bound atacicept in human serum: M. Eslami, et al.; Front. Immunol. 13, 1035556 (2022)
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