AdipoGen Life Sciences

BAFF, Soluble (human) Matched Pair Detection Set

CHF 750.00
In stock
AG-46B-0001-KI011 SetCHF 750.00
Reagents for 5 x 96-well plates
More Information
Product Details
Synonyms BlyS; B Cell Activating Factor
Product Type Kit
Application Set Quantitative ELISA
Specificity Detects human BAFF. Does not detect mouse BAFF.
Crossreactivity Human
Quantity Contains sufficient materials to run ELISAs on 5 x 96-well plates.
Sensitivity 16pg/ml
Range 16 to 1000pg/ml
Sample Type Cell Culture Supernatant
Assay Type Sandwich
Detection Type Colorimetric
Kit Contains 1 vial standard protein (5μg) (lyophilized) [STD]
1 vial coating antibody (120μl) [COAT]
1 vial detection antibody (60μl) [DET]
1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
Shipping and Handling
Shipping BLUE ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Product References
  1. Elevated serum BAFF levels in patients with autoimmunity and lymphoproliferation: A. Janda, et al.; Scand. J. Immunol.74, 518 (2011)
  2. HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes: A.M. Gomez, et al.; J. Immunol. 194, 2300 (2015)
  3. HIV-1-mediated BAFF secretion in macrophages does not require endosomal TLRs, type-I IFN, and Nef, but depends on the cellular phenotype status: A.M. Gomez, et al.; J. Immunol. 196, 3806 (2016)
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