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AdipoGen Life Sciences
anti-TLR3 (mouse), mAb (ABM24E5)
Product Details | |
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Synonyms | Toll-like Receptor 3; CD283 |
Product Type | Monoclonal Antibody |
Properties | |
Clone | ABM24E5 |
Isotype | Rat IgG2bκ |
Immunogen/Antigen | Recombinant mouse TLR3 protein (aa 180-385). |
Application |
Flow Cytometry: (0.5mg/106 cells) |
Crossreactivity | Mouse |
Specificity |
Recognizes mouse TLR3. |
Purity | Protein G purified. |
Concentration | 0.5mg/ml |
Formulation | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
Isotype Negative Control | |
Accession Number | Q99MB1 |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. mTLR3 shows high homology to hTLR3 in their predicted cDNA and protein sequences. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). The high levels of mTLR3 expression in marginal zone B cells perhaps contribute to their ability to clear antigen from the blood. It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.