Incensol

More Information
Product Details
Synonyms	(-)-Incensol; (-)-Incensole; (1R,2S,5E,9E,12S)-1,5,9-Trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol
Product Type	Chemical
Properties
Formula	C₂₀H₃₄O₂
MW	306.5
CAS	22419-74-5
Source/Host Chemicals	Isolated from Boswellia papyrifera.
Purity Chemicals	≥92% (HPLC)
Appearance	Oil.
Solubility	Soluble in DMSO, dichloromethane or ethyl ether. Insoluble in water. Almost insoluble in ethanol or methanol.
InChi Key	SSBZLMMXFQMHDP-REDNKFHQSA-N
Smiles	C/C1=C\CC/C(C)=C/C[C@]2(C(C)C)CC[C@@](C)(O2)[C@@H](O)CC1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Component of the frankincense essential oil.
Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol acetate (Prod. No. AG-CN2-0484).
Potent inhibitor of STAT3. Showed inhibitory activity on IL-6-induced STAT3 activation.
Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines.

Product References

Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri: N. Banno, et al.; J. Ethnopharmacol. 107, 249 (2006)
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri: T. Akihisa, et al.; Biol. Pharm. Bull. 29, 1976 (2006)
Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity: S.I. Ali, et al.; Nat. Prod. Commun. 8, 1365 (2013)
Neuroactive and anti-inflammatory frankincense cembranes: A structure-activity study: F. Pollastro, et al.; J. Nat. Prod. 79, 1762 (2016)

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