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BioViotica
γ-Rubromycin
95
CHF
CHF 95.00
In stock
BVT-0007-M0011 mgCHF 95.00
BVT-0007-M0055 mgCHF 385.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C26H18O12 |
| MW | 522.4 |
| CAS | 27267-71-6 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Red powder. |
| Solubility | Soluble in methylene chloride, DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | CKLKRRFSZZUFKT-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=CC2=CC3=C(O[C@@]4(CC5=C(O)C6=C(C(O)=C5O4)C(=O)C(OC)=CC6=O)CC3)C(O)=C2C(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- HIV-1 reverse transcriptase and human telomerase inhibitor.
- Antibacterial.
- Anticancer agent. ytostatically active against different tumor cell lines.
- Human telomerase inhibitor.
Product References
- Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 170 (1970)
- Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990)
- Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000)
- Structural and biosynthetic investigations of the rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000)
- Determination of the absolute configurations of gamma-rubromycins and related spiro compounds: G. Bringmann, et. al.; Eur. J. Org. Chem. 2000, 2729 (2000)
- Rubromycins: Structurally intriguing, biologically valuable, synthetically challenging antitumour antibiotics: M. Brasholz, et al.; Eur. J. Org. Chem. 3801 (2007)
- Total synthesis of (+/-)-gamma-rubromycin on the basis of two aromatic Pummerer-type reactions: S. Akai, et al.; Angew. Chem. Int. Ed. 46, 7458 (2007)
- Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase: T. Sugiyama, et. al.; J. Biochem. 151, 129 (2012)
- A Convergent Total Synthesis of the Telomerase Inhibitor (±)-γ-Rubromycin: M. Wilsdorf & H.-U. Reißig; Angew. Chem. Int. Ed. 53, 4495 (2014)
- Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products: D.J. Atkinson & M.A. Brimble; Nat. Prod. Rep. 32, 811 (2015)
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