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Cayman
Wedelolactone
75
CHF
CHF 75.00
In stock
CAY-11796-500500 µgCHF 75.00
CAY-11796-11 mgCHF 126.00
CAY-11796-55 mgCHF 367.00
Product Details | |
---|---|
Synonyms | IKK Inhibitor II |
Product Type | Chemical |
Properties | |
Formula | C16H10O7 |
MW | 314.3 |
CAS | 524-12-9 |
Purity Chemicals | ≥98% |
Appearance | A crystalline solid |
Declaration | Manufactured by Cayman Chemicals. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
InChi Key | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
Smiles | OC1=CC2=C(OC(C(C(O)=CC(OC)=C3)=C3O4)=C2C4=O)C=C1O |
Shipping and Handling | |
Shipping | BLUE ICE |
Long Term Storage | -20°C |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Description
Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM. Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM). Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor.