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Cayman
RO8191
49
CHF
CHF 49.00
In stock
CAY-20449-11 mgCHF 49.00
CAY-20449-55 mgCHF 168.00
CAY-20449-1010 mgCHF 236.00
CAY-20449-2525 mgCHF 528.00
| Product Details | |
|---|---|
| Synonyms | Ro 494-8191 |
| Product Type | Chemical |
| Properties | |
| Formula | C14H5F6N5O |
| MW | 373.2 |
| CAS | 691868-88-9 |
| Purity Chemicals | ≥98% |
| Appearance | A crystalline solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GRHYZVJEXKTJOS-UHFFFAOYSA-N |
| Smiles | FC(C1=CC(C(F)(F)F)=C2C(N3C(C=C2)=NC(C4=NN=CO4)=C3)=N1)(F)F |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
RO8191 is an agonist of interferon (IFN) α receptor type 2 (IFNAR2) with antiviral activity (EC50 = 200 nM in an anti-hepatitis C virus (HCV) replicon assay). It exhibits 1:1 binding to the IFNAR2 extracellular domain, indicating RO8191 and IFNAR2 interact at the cell surface. RO8191 induces expression of IFN-stimulated genes, without induction of genes encoding inflammatory cytokines and chemokines, in HCV replicon cells, several cancer cell lines, and human primary hepatocytes. RO8191 induces expression of IFN-stimulated genes in vivo without induction of inflammatory cytokine and chemokine expression in mice. It also reduces HCV titer in HCV-infected humanized liver mice following oral administration.