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Cayman
SN-011
75
CHF
CHF 75.00
In stock
CAY-34890-11 mgCHF 75.00
CAY-34890-55 mgCHF 276.00
CAY-34890-1010 mgCHF 477.00
CAY-34890-2525 mgCHF 1'003.00
| Product Details | |
|---|---|
| Synonyms | GUN35901 |
| Product Type | Chemical |
| Properties | |
| Formula | C25H19FN2O4S |
| MW | 462.5 |
| CAS | 2249435-90-1 |
| Purity Chemicals | ≥98% |
| Appearance | A solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GPXQUPCJIJBXHJ-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(C(NS(=O)(C4=CC=C(C=C4)F)=O)=C3)O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A STING antagonist; binds to the STING cyclic dinucleotide binding site (Kd = 4.03 nM) and inhibits 2'3'-cGAMP-induced Ifnb expression in MEFs, BMDMs, and HFFs (IC50s = 127.5, 107.1, and 502.8 nM, respectively); impairs recruitment of IRF3 or TBK1 to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits HSV-1-induced translocation of STING from the ER to the Golgi at 1 µM; increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutires syndrome at 5 mg/kg.