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AdipoGen Life Sciences
anti-TLR6 (human), mAb (ABM1B50)
Product Details | |
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Synonyms | Toll-like Receptor 6; CD286 |
Product Type | Monoclonal Antibody |
Properties | |
Clone | ABM1B50 |
Isotype | Mouse IgG1κ |
Immunogen/Antigen | Recombinant human TLR6 protein (aa 280-512). |
Application |
Flow cytometry: (0.5µg/106 cells) |
Crossreactivity | Human |
Specificity |
Recognizes human TLR6. |
Purity | Protein G purified. |
Concentration | 0.5mg/ml |
Formulation | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
Isotype Negative Control | |
Accession Number | Q9Y2C9 |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
TLR6 (Toll-like Receptor 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 in complex with TLR2 specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides from Gram-positive bacteria and fungi. The activation cluster TLR2:TLR6:CD14:CD36 signals via MYD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response. In complex with TLR2 recognizes MALP-2, STF, PSM and OspA-L, as well. In response to oxidized low-density lipoprotein (oxLDL) or amyloid-β 42, TLR6 forms a heterodimer with TLR4. This complex rapidly internalizes and triggers inflammatory responses through the NF-κB-dependent MYD88 signaling or via TICAM1 signaling pathways. The complex promotes sterile inflammation in monocytes/macrophages. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Various polymorphism have been associated with inflammatory and tumor pathologies.