(R)-CR8

CHF 70.00
In stock
AG-CR1-0039-M0011 mgCHF 70.00
AG-CR1-0039-M0055 mgCHF 200.00
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Product Details
Synonyms 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine
Product Type Chemical
Properties
Formula C24H29N7O
MW 431.5
CAS 294646-77-8
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or 100% ethanol.
Identity Determined by 1H-NMR.
InChi Key HOCBJBNQIQQQGT-LJQANCHMSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep under inert gas.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor [1].
  • Apoptosis inducer [1].
  • Potent glycogen synthase kinase (GSK-3α/β) inhibitor [1].
Product References
  1. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
  2. Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013)
  3. Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)
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