Actinomycin D

CHF 60.00
In stock
BVT-0089-M0055 mgCHF 60.00
BVT-0089-M02525 mgCHF 180.00
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Product Details
Synonyms Actinomycin IV; Actinomycin C1; Dactinomycin
Product Type Chemical


MW 1255.4
Merck Index 14: 2800
CAS 50-76-0
RTECS AU1575000
Source/Host Chemicals Isolated from Streptomyces parvulus.
Purity Chemicals ≥98% (HPLC)
Appearance Red shiny crystals.
Solubility Soluble in DMSO, 100% ethanol or methanol.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Other Product Data

Sensitive to strong acids and bases.

Smiles CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
After reconstitution protect from light at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic.
  • Antitumor compound [2].
  • Cytotoxic [2].
  • Apoptosis inducer [1, 2, 6, 7].
  • RNA synthesis inhibitor [4].
  • DNA intercalating agent [3, 5].
  • Mcl-1 expression inhibitor [8]
  • p53 pathway activator [9].
Product References
  1. Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle: J.M. Glynn, et al.; Biochem. Soc. Trans. 20, 84S (1992)
  2. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells: J. Kleeff, et al.; Int. J. Cancer 86, 399 (2000)
  3. Influence of DNA base sequence on the binding energetics of actinomycin D: S.A. Bailey, et al.; Biochemistry 32, 5881 (1993)
  4. Effect of actinomycin on RNA synthesis and antibody formation in the anamnestic response in vitro: J.D. Smiley, et al.; J. Exp. Med. 119, 881 (1964)
  5. NMR Solution Structure of a DNA-Actinomycin D Complex Containing a Non-Hydrogen-Bonding Pair in the Binding Site: S.L. Cravens, et al.; J. Am. Chem. Soc. 132, 17588 (2010)
  6. Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes: I. Kalousek, et al.; Anticancer Drugs 18, 763 (2007)
  7. Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells: M.J. Wang, et al.; Neurosci. Res. 59, 40 (2007)
  8. Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression: K.E. Olberding, et al.; Cancer Biol. Ther. 10, 930 (2010)
  9. Specific activation of the p53 pathway by low dose actinomycin D: M. L. Choong, et al.; Cell Cycle 8, 2810 (2009)
  10. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes: T. Katayoshi, et al.; J. Photochem. Photobiol. B 221, 112238 (2021)
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