Kojic acid

CHF 55.00
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BVT-0019-M01010 mgCHF 55.00
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Product Details
Synonyms 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; KOJ
Product Type Chemical


MW 142.1
Merck Index 14: 5317
CAS 501-30-4
RTECS UQ0875000
Source/Host Chemicals Isolated from Aspergillus sp.
Purity Chemicals ≥99% (NMR)
Appearance White solid.
Solubility Soluble in DMSO, methanol or water.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Smiles OCC1=CC(=O)C(O)=CO1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Mycotoxin. Chelation agent with polyfunctional skeleton for development of biologically active compounds.
  • Moderate antibacterial agent.
  • Tyrosinase inhibitor. Inhibits catecholase activity of tyrosinase.
  • Anti-melanogenic. Skin whitening agent.
  • Antioxidant. Reactive oxygen species (ROS) scavenger.
  • D-Amino acid oxidase (DAAO) inhibitor.
  • Shown to inhibit NF-kB activation.
  • Inducer of macrophage activation.
  • Radioprotectant activity.
  • Antileishmanial agent.
  • Insecticidal.
  • Antifungal chemosensitizer.
  • Used in cosmetics and as food additive.
Product References
  1. The contitution of kojic acid, a gamma-pyrone derivative of Aspergillus oryzae from carbohydrates: T. Yabuta; J. Chem. Soc. 125, 575 (1924)
  2. Toxicity and Antibiotic Activity of Kojic Acid Produced by Aspergillus luteo-virescens: H.E. Morton, et al.; J. Bacteriol. 50, 579 (1945)
  3. Kojic acid scavenges free radicals while potentiating leukocyte functions including free radical generation: Y. Niwa & H. Akamatsu; Inflammation 15, 303 (1991)
  4. Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase: J. Cabanes, et al.; J. Pharm. Pharmacol. 46, 982 (1994)
  5. The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions: A. Garcia & J.E. Fulton Jr.; Dermatol. Surg. 22, 443 (1996)
  6. Kojic acid--a new leading molecule for a preparation of compounds with an anti-neoplastic potential: L.  Novotny, et al.; Neoplasma 46, 89 (1999) (Review)
  7. Kojic acid, a potential inhibitor of NF-kappaB activation in transfectant human HaCaT and SCC-13 cells: K.Y. Moon, et al.; Arch. Pharm. Res. 24, 307 (2001)
  8. Effects of mycotoxins, kojic acid and oxalic acid, on biological fitness of Lygus hesperus (Heteroptera: Miridae): J. Alverson; J. Invertebr. Pathol. 83, 60 (2003)
  9. From miso, sake and skoyu to cosmetics: a century of science for kojic acid: R. Bentley; Nat. Prod. Rep. 23, 1046 (2006) (Review)
  10. Kojic acid and its manganese and zinc complexes as potential radioprotective agents: S. Emami, et al.; Bioorg. Med. Chem. Lett. 17, 45 (2007)
  11. Kojic acid, a secondary metabolite from Aspergillus sp., acts as an inducer of macrophage activation: A.P. Rodrigues, et al.; Cell Biol. Int. 35, 335 (2011)
  12. Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase: M. Raje, et al.; Bioorg. Med. Chem. Lett. 23, 3910 (2013)
  13. Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid: J.H. Kim, et al.; Molecules 18, 1564 (2013)
  14. A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent: A.P. Rodrigues, et al.; PLoS One 9, e91259 (2014)
  15. A tyrosinase inhibitor from Aspergillus niger: K.Y. Vasantha, et al.; J. Food Sci. Tech. 51, 2877 (2014)
  16. Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid: M. Srisayam, et al.; J. Dermatol. Sci. 73, 241 (2014)
  17. Feeding Deterrence, acute toxicity and sublethal growth effects of kojic acid isolated from Aspergillus funiculosus: S. Busi, et al.; Nat. Prod. J. 4, 18 (2014)
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