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BioViotica
Kojic acid
55
CHF
CHF 55.00
In stock
BVT-0019-M01010 mgCHF 55.00
| Product Details | |
|---|---|
| Synonyms | 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; KOJ |
| Product Type | Chemical |
| Properties | |
| Formula |
C6H6O4 |
| MW | 142.1 |
| Merck Index | 14: 5317 |
| CAS | 501-30-4 |
| RTECS | UQ0875000 |
| Source/Host Chemicals | Isolated from Aspergillus sp. |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, methanol or water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | BEJNERDRQOWKJM-UHFFFAOYSA-N |
| Smiles | OCC1=CC(=O)C(O)=CO1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Mycotoxin. Chelation agent with polyfunctional skeleton for development of biologically active compounds.
- Moderate antibacterial agent.
- Tyrosinase inhibitor. Inhibits catecholase activity of tyrosinase.
- Anti-melanogenic. Skin whitening agent.
- Antioxidant. Reactive oxygen species (ROS) scavenger.
- D-Amino acid oxidase (DAAO) inhibitor.
- Shown to inhibit NF-kB activation.
- Inducer of macrophage activation.
- Radioprotectant activity.
- Antileishmanial agent.
- Insecticidal.
- Antifungal chemosensitizer.
- Used in cosmetics and as food additive.
Product References
- The contitution of kojic acid, a gamma-pyrone derivative of Aspergillus oryzae from carbohydrates: T. Yabuta; J. Chem. Soc. 125, 575 (1924)
- Toxicity and Antibiotic Activity of Kojic Acid Produced by Aspergillus luteo-virescens: H.E. Morton, et al.; J. Bacteriol. 50, 579 (1945)
- Kojic acid scavenges free radicals while potentiating leukocyte functions including free radical generation: Y. Niwa & H. Akamatsu; Inflammation 15, 303 (1991)
- Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase: J. Cabanes, et al.; J. Pharm. Pharmacol. 46, 982 (1994)
- The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions: A. Garcia & J.E. Fulton Jr.; Dermatol. Surg. 22, 443 (1996)
- Kojic acid--a new leading molecule for a preparation of compounds with an anti-neoplastic potential: L. Novotny, et al.; Neoplasma 46, 89 (1999) (Review)
- Kojic acid, a potential inhibitor of NF-kappaB activation in transfectant human HaCaT and SCC-13 cells: K.Y. Moon, et al.; Arch. Pharm. Res. 24, 307 (2001)
- Effects of mycotoxins, kojic acid and oxalic acid, on biological fitness of Lygus hesperus (Heteroptera: Miridae): J. Alverson; J. Invertebr. Pathol. 83, 60 (2003)
- From miso, sake and skoyu to cosmetics: a century of science for kojic acid: R. Bentley; Nat. Prod. Rep. 23, 1046 (2006) (Review)
- Kojic acid and its manganese and zinc complexes as potential radioprotective agents: S. Emami, et al.; Bioorg. Med. Chem. Lett. 17, 45 (2007)
- Kojic acid, a secondary metabolite from Aspergillus sp., acts as an inducer of macrophage activation: A.P. Rodrigues, et al.; Cell Biol. Int. 35, 335 (2011)
- Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase: M. Raje, et al.; Bioorg. Med. Chem. Lett. 23, 3910 (2013)
- Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid: J.H. Kim, et al.; Molecules 18, 1564 (2013)
- A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent: A.P. Rodrigues, et al.; PLoS One 9, e91259 (2014)
- A tyrosinase inhibitor from Aspergillus niger: K.Y. Vasantha, et al.; J. Food Sci. Tech. 51, 2877 (2014)
- Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid: M. Srisayam, et al.; J. Dermatol. Sci. 73, 241 (2014)
- Feeding Deterrence, acute toxicity and sublethal growth effects of kojic acid isolated from Aspergillus funiculosus: S. Busi, et al.; Nat. Prod. J. 4, 18 (2014)
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