CHF 110.00
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BVT-0185-M0011 mgCHF 110.00
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Product Details
Synonyms Antibiotic 255-E; Antibiotic 5001B; Antibiotic 56-62; Antibiotic 846I; Gopalamicin; Salbomycin; Azalomycin B; SNA 4606-3
Product Type Chemical
Formula C54H88O18
MW 1025.3
CAS 37318-06-2
Source/Host Chemicals Isolated from Streptomyces sp. MT-1.
Purity Chemicals ≥95% (HPLC)
Appearance White powder.
Solubility Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Other Product Data May undergo transformation to methyl ketal on storage in methanol. We recommend the use of fresh solutions.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic.
  • Active against Gram-positive bacteria, protozoa and tumors.
  • Antitumor agent. Autophagy inducer and antiangiogenic agent.
  • Testosterone 5α-reductase inhibitor.
  • Nitric oxide synthase (NOS) inhibitor.
  • Immunosuppressive.
  • Enhances the antifungal activity of rapamycin.
Product References
  1. Isolation and characterization of Niphithricins A, B and Elaiophylin, antibiotics produced by Streptomyces violaceoniger: H.-P. Fiedler et al.; J Antibiot. 34, 1107 (1981)
  2. Strukturaufklärung von Elaiophylin: Spektroskopische Untersuchungen und Abbau: H. Kaiser & W. Keller-Schierlein; Helv. Chim. Acta 64, 407 (1981)
  3. Röntgenstrukturanalyse von Elaiophylin: K. Neupert-Laves & M. Dobler; Helv. Chim. Acta 65, 262 (1982)
  4. Elaiophylin derivatives and their biological activities: P. Hammann et al.; J. Antibiot. 43, 1431 (1990)
  5. The biogenetic origin of the carbon skeleton and the oxygen atoms of Elaiophylin, a symmetric macrodiolide antibiotic: M. Gerlitz et al.; J. Org. Chem. 57, 4030 (1992)
  6. Immunosuppressive activity of elaiophylins: S. Y. Lee et al.; J. Microbiol. Biotechnol. 7, 272 (1997)
  7. SNA-4606-1, a new member of Elaiophylins with enzyme inhibition activity against testosterone 5 α-reductase: M. Nakakoshi et al.; J. Antibiot. 52, 175 (1999)
  8. Enhancement of the antifungal activity of Rapamycin by the coproduced Elaiophylin and Nigericin: A. Fang et al.; J. Antibiot. 53, 158 (2000)
  9. Cation selective ion channels formed by macrodiolide antibiotic Elaiophylin in lipid bilayer membranes: P.A. Grigoriev et al.; Bioelectrochem. 54, 11 (2001)
  10. Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties: C. Cui et al.; Chinese J. Antibiot. 26, 165-170 (2001)
  11. In vitro and in vivo antiprotozoal activities of bispolides and their derivatives: K. Otoguru et al.; J. Antibiot. 63, 275 (2010)
  12. Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells: X. Zhao, et al.; Autophagy 11, 1849 (2015)
  13. The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis: G. Wang, et al.; Cancer Biol. Ther. 18, 584 (2017)
  14. Antiangiogenic potential of microbial metabolite elaiophylin for targeting tumor angiogenesis: H.N. Lim, et al.; Molecules 23, 563 (2018)
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