Finasteride

More Information
Product Details
Synonyms	MK 906; L-652,931; BRN 4269024
Product Type	Chemical
Properties
Formula	C₂₃H₃₆N₂O₂
MW	372.5
Merck Index	14: 4082
CAS	98319-26-7
RTECS	CL5245000
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO, DMF, ethanol or methanol. Sparingly soluble in water.
InChi Key	DBEPLOCGEIEOCV-WSBQPABSSA-N
Smiles	[H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Potent, specific and competitive inhibitor of type II 5α-reductase (enzyme which converts testosterone to the more potent 5α-dihydrotestosterone) [1, 3].
Anticancer compound [2, 6, 7].
Apoptosis modulator [2, 6].
Enhances the action of GABA at GABA(A) receptors, which leads to neurological implications [4].
Inhibit testosterone-induced type I procollagen and TGF-β1 expression in human scalp dermal fibroblasts in a model of androgenic alopecia [5].
Drug for the treatment of male androgenetic alopecia [8].
Potential role in neuropsychiatric disorders [9].
Shown to reduce L-DOPA-induced dyskinesia in rodent models for Parkinson’s disease [10].

Product References

Finasteride: the first 5 alpha-reductase inhibitor: S.L. Sudduth & M.J. Koronkowski; Pharmacotherapy 13, 309 (1993)
Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins: H. Huynh; Int. J. Oncol. 20, 1297 (2002)
Steroid 5α-reductase inhibitors: R. Flores, et al.; Mini Rev. Med. Chem. 3, 225 (2003)
A new look at the 5alpha-reductase inhibitor finasteride: D.A. Finn, et al.; CNS Drug Rev. 12, 53 (2006)
Perifollicular fibrosis: Pathogenetic role in androgenetic alopecia; H.G. Yoo, et al.; Biol. Pharm. Bull. 29, 1246 (2006)
Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line: J.M. Golbano, et al.; Int. J. Oncol. 32, 919 (2008)
Molecular profiles of finasteride effects on prostate carcinogenesis: Cancer Prev. Res. 2, 518 (2009)
Male androgenetic alopecia: D. Rathnayake & R. Sinclair; Expert Opin. Pharmacother. 11, 1295 (2010)
Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders: S. Paba, et al.; Curr. Pharm. Des. 17, 151 (2011)
5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction: S. Fanni, et al.; Neurobiol. Dis. 121, 120 (2018)

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