AdipoGen Life Sciences


CHF 25.00
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AG-CR1-3589-M02525 mgCHF 25.00
AG-CR1-3589-M100100 mgCHF 60.00
AG-CR1-3589-M500500 mgCHF 240.00
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Product Details
Synonyms MK 906; L-652,931; BRN 4269024
Product Type Chemical


MW 372.5
Merck Index 14: 4082
CAS 98319-26-7
RTECS CL5245000
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, DMF, ethanol or methanol. Sparingly soluble in water.
Smiles [H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent, specific and competitive inhibitor of type II 5α-reductase (enzyme which converts testosterone to the more potent 5α-dihydrotestosterone) [1, 3].
  • Anticancer compound [2, 6, 7].
  • Apoptosis modulator [2, 6].
  • Enhances the action of GABA at GABA(A) receptors, which leads to neurological implications [4].
  • Inhibit testosterone-induced type I procollagen and TGF-β1 expression in human scalp dermal fibroblasts in a model of androgenic alopecia [5].
  • Drug for the treatment of male androgenetic alopecia [8].
  • Potential role in neuropsychiatric disorders [9].
  • Shown to reduce L-DOPA-induced dyskinesia in rodent models for Parkinson’s disease [10].
Product References
  1. Finasteride: the first 5 alpha-reductase inhibitor: S.L. Sudduth & M.J. Koronkowski; Pharmacotherapy 13, 309 (1993)
  2. Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins: H. Huynh; Int. J. Oncol. 20, 1297 (2002)
  3. Steroid 5α-reductase inhibitors: R. Flores, et al.; Mini Rev. Med. Chem. 3, 225 (2003)
  4. A new look at the 5alpha-reductase inhibitor finasteride: D.A. Finn, et al.; CNS Drug Rev. 12, 53 (2006)
  5. Perifollicular fibrosis: Pathogenetic role in androgenetic alopecia; H.G. Yoo, et al.; Biol. Pharm. Bull. 29, 1246 (2006)
  6. Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line: J.M. Golbano, et al.; Int. J. Oncol. 32, 919 (2008)
  7. Molecular profiles of finasteride effects on prostate carcinogenesis: Cancer Prev. Res. 2, 518 (2009)
  8. Male androgenetic alopecia: D. Rathnayake & R. Sinclair; Expert Opin. Pharmacother. 11, 1295 (2010)
  9. Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders: S. Paba, et al.; Curr. Pharm. Des. 17, 151 (2011)
  10. 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction: S. Fanni, et al.; Neurobiol. Dis. 121, 120 (2018)
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