CHF 115.00
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BVT-0185-M0011 mgCHF 115.00
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Product Details
Synonyms Antibiotic 255-E; Antibiotic 5001B; Antibiotic 56-62; Antibiotic 846I; Gopalamicin; Salbomycin; Azalomycin B; SNA 4606-3
Product Type Chemical


MW 1025.3
CAS 37318-06-2
Source/Host Chemicals Isolated from Streptomyces sp. MT-1.
Purity Chemicals ≥95% (HPLC)
Appearance White powder.
Solubility Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Other Product Data

May undergo transformation to methyl ketal on storage in methanol. We recommend the use of fresh solutions.

Smiles [H][C@@]1(C[C@H](O)[C@H](O)[C@H](C)O1)O[C@@H]1C[C@@](O)(O[C@H](C)[C@H]1CC)[C@@H](C)[C@H](O)[C@H](C)[C@@]1([H])OC(=O)\C=C\C=C\[C@H](C)[C@]([H])(OC(=O)\C=C\C=C\[C@@H]1C)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O[C@@]2([H])C[C@H](O)[C@H](O)[C@H](C)O2)[C@H](CC)[C@@H](C)O1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic.
  • Active against Gram-positive bacteria, protozoa and tumors.
  • Antitumor agent. Autophagy inducer and antiangiogenic agent.
  • Testosterone 5α-reductase inhibitor.
  • Nitric oxide synthase (NOS) inhibitor.
  • Immunosuppressive.
  • Enhances the antifungal activity of rapamycin.
Product References
  1. Isolation and characterization of Niphithricins A, B and Elaiophylin, antibiotics produced by Streptomyces violaceoniger: H.-P. Fiedler et al.; J Antibiot. 34, 1107 (1981)
  2. Strukturaufklärung von Elaiophylin: Spektroskopische Untersuchungen und Abbau: H. Kaiser & W. Keller-Schierlein; Helv. Chim. Acta 64, 407 (1981)
  3. Röntgenstrukturanalyse von Elaiophylin: K. Neupert-Laves & M. Dobler; Helv. Chim. Acta 65, 262 (1982)
  4. Elaiophylin derivatives and their biological activities: P. Hammann et al.; J. Antibiot. 43, 1431 (1990)
  5. The biogenetic origin of the carbon skeleton and the oxygen atoms of Elaiophylin, a symmetric macrodiolide antibiotic: M. Gerlitz et al.; J. Org. Chem. 57, 4030 (1992)
  6. Immunosuppressive activity of elaiophylins: S. Y. Lee et al.; J. Microbiol. Biotechnol. 7, 272 (1997)
  7. SNA-4606-1, a new member of Elaiophylins with enzyme inhibition activity against testosterone 5 α-reductase: M. Nakakoshi et al.; J. Antibiot. 52, 175 (1999)
  8. Enhancement of the antifungal activity of Rapamycin by the coproduced Elaiophylin and Nigericin: A. Fang et al.; J. Antibiot. 53, 158 (2000)
  9. Cation selective ion channels formed by macrodiolide antibiotic Elaiophylin in lipid bilayer membranes: P.A. Grigoriev et al.; Bioelectrochem. 54, 11 (2001)
  10. Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties: C. Cui et al.; Chinese J. Antibiot. 26, 165-170 (2001)
  11. In vitro and in vivo antiprotozoal activities of bispolides and their derivatives: K. Otoguru et al.; J. Antibiot. 63, 275 (2010)
  12. Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells: X. Zhao, et al.; Autophagy 11, 1849 (2015)
  13. The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis: G. Wang, et al.; Cancer Biol. Ther. 18, 584 (2017)
  14. Antiangiogenic potential of microbial metabolite elaiophylin for targeting tumor angiogenesis: H.N. Lim, et al.; Molecules 23, 563 (2018)
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