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SouthBayBio
SENP1 (catalytic domain) (human) (rec.) (His)
275
CHF
CHF 275.00
In stock
SBB-DE0026-C05050 µgCHF 275.00
| Product Details | |
|---|---|
| Synonyms | Sentrin-specific Protease 1; Sentrin/SUMO-specific Protease SENP1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human SENP1 (catalytic domain aa 387-644) (Accession Nr. Q9P0U3) fused at the N-terminus to a His-tag. |
| Crossreactivity | Human |
| Application | Typical working concentration range is 1-10nM. |
| MW | ~32kDa |
| Purity | ≥95% (SDS-PAGE) |
| Concentration | Lot dependent. |
| Accession Number | Q9P0U3 |
| Formulation | Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 10% glycerol, 1mM TCEP. |
| Other Product Data |
Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer Our product description may differ slightly from the original manufacturers product datasheet. |
| Declaration | Manufactured by South Bay Bio. |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -80°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
SUMO/Sentrin Specific Peptidase 1 (SENP1) is a member of the SENP family of proteases, which belong to the group of cysteine-type peptidases. SENP1 is a SUMO-specific enzyme that catalyzes two essential functions. Processing the full-length versions of SUMO1, SUMO2 and SUMO3 into its mature forms and the deconjugation of SUMOylated proteins. SENP1 is expressed in many organs and is localized in the nucleus as well as the cytoplasm. SENP1 is thought to play a role in the development, progression and metastasis of prostate cancer and has been shown to regulate erythropoietin production during hypoxia by regulating the stability of HIF1-α. Furthermore, SENP1 deconjugates SUMO1 from HIPK2, HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. SENP1 has been shown to desumoylate CCAR2, which subsequently decreases the interaction with SIRT1.