SENP1 (catalytic domain) (human) (rec.) (His)

CHF 155.00
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SBB-DE0026-C05050 µgCHF 155.00
 
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Product Details
Synonyms Sentrin-specific Protease 1; Sentrin/SUMO-specific Protease SENP1
Product Type Protein
Properties
Source/Host E. coli
Sequence Human SENP1 (catalytic domain aa 387-644) (Accession Nr. Q9P0U3) fused at the N-terminus to a His-tag.
Crossreactivity Human
Application Typical working concentration range is 1-10nM.
MW ~32kDa
Purity ≥95% (SDS-PAGE)
Concentration Lot dependent.
Accession Number Q9P0U3
Formulation Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 10% glycerol, 1mM TCEP.
Other Product Data Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by South Bay Bio.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -80°C
Long Term Storage -80°C
Handling Advice Aliquot to avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
SUMO/Sentrin Specific Peptidase 1 (SENP1) is a member of the SENP family of proteases, which belong to the group of cysteine-­type peptidases. SENP1 is a SUMO-specific enzyme that catalyzes two essential functions. Processing the full-length versions of SUMO1, SUMO2 and SUMO3 into its mature forms and the deconjugation of SUMOylated proteins. SENP1 is expressed in many organs and is localized in the nucleus as well as the cytoplasm. SENP1 is thought to play a role in the development, progression and metastasis of prostate cancer and has been shown to regulate erythropoietin production during hypoxia by regulating the stability of HIF1-α. Furthermore, SENP1 deconjugates SUMO1 from HIPK2, HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. SENP1 has been shown to desumoylate CCAR2, which subsequently decreases the interaction with SIRT1.
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