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AdipoGen Life Sciences
anti-TLR2, mAb (ABM3A87) (APC)
Product Details | |
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Synonyms | Toll-like Receptor 2; CD282; Toll/Interleukin-1 Receptor-like Protein 4; TIL4 |
Product Type | Monoclonal Antibody |
Properties | |
Clone | ABM3A87 |
Isotype | Mouse IgG1κ |
Immunogen/Antigen | Recombinant human TLR2 protein (aa 180-420). |
Label/Conjugates | APC |
Application |
Flow Cytometry: (0.5-1μg/106 cells) |
Crossreactivity |
Human Mouse |
Specificity |
Recognizes human and mouse TLR2. |
Purity | Protein G purified. |
Concentration | 0.2mg/ml |
Formulation | Liquid. In PBS containing 0.05% sodium azide. |
Isotype Negative Control | |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice |
Do not freeze. Protect from light. |
Use/Stability | Stable for at least 6 months after receipt when stored at +4°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.