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AdipoGen Life Sciences
anti-Stearoyl-CoA Desaturase-1 (mouse), pAb
390
CHF
CHF 390.00
In stock
AG-25A-0031-C100100 µgCHF 390.00
Figure 1: Western blot analysis using anti-SCD1 (mouse), pAb (Prod. No. AG-25A-0031) at 1:2'000 dilution.
1: Mouse liver cell lysate.
1: Mouse liver cell lysate.
| Product Details | |
|---|---|
| Synonyms | SCD1; Acyl-CoA Desaturase 1; Fatty Acid Desaturase 1 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Synthetic peptide corresponding to aa 21-33 (A21PPSGNEREKVKT33) of mouse SCD1. |
| Application |
ELISA: (direct and indirect: 1:2’000-1:5’000) |
| Crossreactivity | Mouse |
| Specificity |
Recognizes mouse SCD1. Detects a band of ~41kDa by Western Blot. |
| Purity Detail | Protein A-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The enzyme is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. Several SCD isoforms (SCD1, -2, and -3) exist in the mouse. Mice with a targeted disruption of the SCD1 isoform had reduced body adiposity, increased insulin sensitivity, and resistance to diet-induced weight gain. The protection from obesity involved increased energy expenditure and increased oxygen consumption. SCD1 deficiency shows activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.
Product References
- Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by boiogito, a Japanese herbal medicine, in mice: S. Watanabe, et al.; Trad. Kampo Med. 3, 9 (2016)