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AdipoGen Life Sciences
anti-NFATc1, pAb (IG-205)
380
CHF
CHF 380.00
In stock
AG-25T-0110-C05050 µgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | Nuclear Factor of Activated T Cells; Cytoplasmic 1; NFAT Transcription Complex Cytosolic Component; NF-ATc1 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant N-terminal human NFATc1 fragment fused to a GST-tag. |
| Application |
ChIP: (1:200) |
| Crossreactivity | Human |
| Specificity |
Recognizes all known human NFATc1 isoforms. |
| Purity | Antigen affinity purified. |
| Concentration | 500μg/ml |
| Formulation | Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. |
| Isotype Negative Control | |
| Accession Number | UniProt ID O95644: NFATc1 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
NFATc1 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 or IL-4 gene transcription. It controls gene expression in embryonic cardiac cells. Regulates not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Product References
- Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells: M. Glazova, et al.; Mol. Brain Res. 138, 116 (2005)
- Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006)
- Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008)
- Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter: S. Klein-Hessling, et al.; J. Biol. Chem. 283, 31030 (2008)
- Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-κB and NFAT: K. Silbermann, et al.; J. Gen. Virol. 89, 2788 (2008)
- Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase: A. Nayak, et al.; J. Biol. Chem. 284, 10935 (2009)
- NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network: S. Bhattacharyya, et al.; J. Exp. Med. 208, 823 (2011)
- NFATc1 induction in peripheral T and B lymphocytes: M. Hock, et al.; J. Immunol. 190, 2345 (2013)
- An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development: A.K. Patra, et al.; Nat. Immunol. 14, 127 (2013)
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