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AdipoGen Life Sciences
FABP4 (human) (rec.) (His)
250
CHF
CHF 250.00
In stock
AG-40A-0035-C05050 µgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | Fatty Acid Binding Protein 4; Adipocyte Fatty Acid Binding Protein; AFABP; ALBP; Adipocyte Lipid Binding Protein |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human FABP4 (aa 1-132) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~16kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 200mM NaCl. |
| Other Product Data |
UniProt link P15090: FABP4 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
FABP4 is a fatty acid binding protein in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs regulate the fatty acid uptake, transport, and metabolism. aP2, the mouse form of FABP4, seems to be central to the pathway that links obesity to insulin resistance. aP2 was shown to be an adipokine linking adipocytes to hepatic glucose production and that neutralizing secreted aP2 may represent an effective therapeutic strategy against diabetes.
Product References
- Circulating Adipocyte Fatty Acid-Binding Protein Induces Insulin Resistance in Mice In Vivo: S. Kralisch, et al.; Obesity 23, 1007 (2015)
- The adipokine FABP4 is a key regulator of neonatal glucose homeostasis: I. Ron, et al.; JCI Insight 6, e138288 (2021)
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