ANGPTL3 (fibrinogen-like domain) (human) (rec.)

CHF 290.00
In stock
AG-40A-0071Y-C01010 µgCHF 290.00
AG-40A-0071Y-C05050 µgCHF 830.00
Replaces Prod. No. AG-40A-0071
More Information
Product Details
Synonyms Angiopoietin-like Protein 3; Angiopoietin-5; ANG-5
Product Type Protein
Source/Host HEK 293 cells

Fibrinogen-like domain of human ANGPTL3 (aa 224-460) is fused at the N-terminus to a FLAG®-tag.

Crossreactivity Human
MW ~35-38kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 50µg size: 1 mg/ml
Reconstitution 10µg size: Reconstitute with 100µl sterile water.
50µg size: Reconstitute with 50µl sterile water.
Accession Number Q9Y5C1
Formulation Lyophilized. Contains PBS.
Other Product Data

UniProt link Q9Y5C1: ANGPTL3 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

ANGPTL3 (Angiopoietin-like protein 3) regulates angiogenesis and also directly regulates lipid, glucose and energy metabolism. Angiopoietin-like 3 (ANGPTL3) is a regulator of plasma triglyceride (TRG) levels due to its inhibitory action on the activity of lipoprotein lipase (LPL). ANGPTL3 induces angiogenesis by binding to integrin αvβ3. ANGPTL3 is predominantly produced in the liver and can therefore be classified as a hepatokine. In the human plasma, ANGPTL3 is cleaved to release two fragments: a N-terminal coiled-coil domain-containing fragment (aa17-207) important for inhibiting the lipolysis of triglyceride and the C-terminal fibrinogen-like domain-containing fragment (aa208-460).

Product References
  1. Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors: H.E. Broxmeyer, et al.; Blood Cells Mol. Dis. 48, 25 (2012)
  2. The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway: S. Bini, et al.; Biomolecules 12, 585 (2022)
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