LIGHT, Soluble (human) (rec.)

CHF 150.00
In stock
AG-40B-0009-C01010 µgCHF 150.00
AG-40B-0009-30103 x 10 µgCHF 300.00
More Information
Product Details
Synonyms HVEML; Tumor Necrosis Factor Ligand Superfamily Member 14; TNFSF14; CD258
Product Type Protein
Properties
Source/Host CHO cells
Sequence Human LIGHT (aa 89-240) is fused at the N-terminus to a FLAG®-tag.
Crossreactivity Human
Mouse
Specificity Binds to human and mouse LTβR and human HVEM and DcR3.
MW ~25kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data

UniProt link O43557: LIGHT (human)AfCS Signalling Gateway link A001406: LIGHT (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-κB, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Product References
  1. Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB: M. Lubrano di Ricco, et al.; Eur. J. Immunol. ahead of print (2020) 
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