LIGHT, Soluble (human) (rec.)
|Synonyms||HVEML; Tumor Necrosis Factor Ligand Superfamily Member 14; TNFSF14; CD258|
|Sequence||Human LIGHT (aa 89-240) is fused at the N-terminus to a FLAG®-tag.|
|Specificity||Binds to human and mouse LTβR and human HVEM and DcR3.|
|Endotoxin Content||<0.01EU/μg purified protein (LAL test; Lonza).|
|Concentration||0.1mg/ml after reconstitution.|
|Reconstitution||Reconstitute with 100μl sterile water.|
|Formulation||Lyophilized. Contains PBS.|
|Other Product Data||
FLAG is a registered trademark of Sigma-Aldrich Co.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-κB, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
- Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB: M. Lubrano di Ricco, et al.; Eur. J. Immunol. ahead of print (2020)