EGFR, Soluble (human) (rec.)

CHF 595.00
In stock
AG-40T-0041-C02525 µgCHF 595.00
 
More Information
Product Details
Synonyms Epidermal Growth Factor Receptor; ERBB1; HER1
Product Type Protein
Properties
Source/Host Sf9 cells
Sequence Human EGFR (629aa) is fused at the C-terminus to a Strep-tag.
Crossreactivity Human
MW ~85kDa
Purity ≥90% (SDS-PAGE)
Reconstitution Soluble in water and most aqueous buffers. Reconstitute with PBS or medium to a concentration of not lower than 50µg/ml.
Formulation Lyophilized.
Other Product Data UniProt link P00533: EGFR (human)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
EGFR has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGFR signaling has also been shown to play a role in carcinogenesis.
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