EGFR, Soluble (human) (rec.)
AG-40T-0041-C02525 µgCHF 595.00
|Synonyms||Epidermal Growth Factor Receptor; ERBB1; HER1|
|Sequence||Human EGFR (629aa) is fused at the C-terminus to a Strep-tag.|
|Reconstitution||Soluble in water and most aqueous buffers. Reconstitute with PBS or medium to a concentration of not lower than 50µg/ml.|
|Other Product Data||UniProt link P00533: EGFR (human)|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
|Use/Stability||Stable for at least 6 months after receipt when stored at -20°C.|
|Product Specification Sheet|
EGFR has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGFR signaling has also been shown to play a role in carcinogenesis.