Zinc-α-2-glycoprotein (human) TurboELISA Kit

CHF 720.00
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AG-48B-1000-KI011 KitCHF 720.00
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Product Details
Synonyms Zn-α-2-GP; Zn-α-2-Glycoprotein; ZAG; ZA2G; AZGP1; ZNGP1
Product Type Kit
Properties
Application Set Quantitative ELISA
Specificity Detects human Zinc-α-2-glycoprotein. Does not detect mouse Zinc-α-2-glycoprotein.
Crossreactivity Human
Quantity 1 x 96 wells
Sensitivity 0.23 ng/ml
Range 0.9375 to 60 ng/ml
Sample Type Cell Culture Supernatant
Plasma
Serum
Assay Type Sandwich
Detection Type Colorimetric
Other Product Data TRADEMARKS - TurboELISA™ and Turbo-coated Plate™ are Trademarks of Adipogen Life Sciences.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Plate and reagents should reach room temperature before use.
Use/Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Documents
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

This assay is a less than 1 hour sandwich Enzyme Linked-Immunosorbent Assay (ELISA) for quantitative determination of human Zinc-α-2-glycoprotein in biological fluids. Zinc-α-2-glycoprotein (ZAG) was first identified in the 1960s, and it's name derives from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently, the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than β2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its α1 and α2 domain helices.

Product References
  1. Development of a Dynamic Multi-Protein Signature of Postoperative Delirium: S.M. Vasunilashorn, et al.; The Journals of Gerontology: Series A, gly036 (2018)
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