LysoGlow84™

CHF 270.00
In stock
AG-CMA-1005-M0011 mgCHF 270.00
More Information
Product Details
Synonyms 4-(Naphthalene-2-yl)-1H-imidazo[4,5-c]pyridine . TFA
Product Type Chemical
Properties
Formula

C16H12N3 . C2F3O2

MW 246.3 . 113.0
CAS 1782983-52-1
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (NMR)
Appearance Light yellow solid.
Solubility Soluble in DMSO, methanol or other polar solvents. Poorly soluble in water at pH8 to pH12.
Identity Determined by 1H-NMR.
Other Product Data

Fluorescence/Spectral properties:
Excitation 310 - 380nm; maximum at ~320nm
Emission 400 - 520nm; maximum at 440nm (pH3 to pH6) and 400nm (pH 8 to pH 13)

Prepare a 10mM stock solution in MeOH or DMSO:
Dissolve 1mg of LysoGlow84 in 278µl methanol, mix gently until the compound is completely dissolved. The solution should show a homogenous yellow color. Use fresh preparations or aliquot and freeze immediately. LysoGlow84 is light sensitive, avoid long exposure to direct light or other bright light sources. Avoid freeze/thaw cycles of solutions.

InChi Key SSYNPCHXJHAMNE-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Protect from light and moisture.
Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Stable for at least 1 year after receipt when stored at +4°C.
Stock solutions are stable for at least 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell/membrane permeable, non-toxic, pH-sensitive fluorescent dye (blue-green range) for live imaging of pH alteration in acidic organelles, lysosomes, autophagolysosomes, vesicles, cells, tissue and even small, transparent whole animals without side effects.
  • Useful as intracellular pH indicator with a wide range of fluorescence (pH 3 to pH 13). 
  • pH-dependent dual-emission peaks, can be used for ratiometric evaluation of pH (F400/440).
  • No esterases are involved, therefore no toxic by-products occur.
  • Long-term stable; is barely metabolized.
  • Fluorescence co-localizes with LysoTracker® Red DND-99. (LysoTracker® is a registered trademark of Molecular Probes, Inc.)
Product References
  1. The chemically synthesized Ageladine A-derivative LysoGlow84 stains lysosomes in viable mammalian brain cells and specific structures in the marine flatworm Macrostomum lignano: T. Mordhorst, et al.; Mar. Drugs 13, 920 (2015)
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