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AdipoGen Life Sciences
Anomalin A
150
CHF
CHF 150.00
In stock
AG-CN2-0006-M0011 mgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | 2,3,6,8-Tetrahydroxy-1-methylxanthone |
| Product Type | Chemical |
| Properties | |
| Formula |
C14H10O6 |
| MW | 274.1 |
| CAS | 548740-86-9 |
| Source/Host Chemicals | Isolated from marine fungus Arthrinium sp. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellowish solid. |
| Solubility | Soluble in 100% ethanol or DMSO. |
| InChi Key | YPBXGIBBOZOVPM-UHFFFAOYSA-N |
| Smiles | [H]C1=C(O)C(O)=C(C)C2=C1OC1=C(C(O)=CC(O)=C1)C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antiproliferative agent against selected cancer cell lines. Inhibits protein kinases ALK, ARK5, Aurora-B, AXL, FAK, IGF1-R, MET, PIM1, PLK1, PRK1, SRC, and VEGF-R2 with IC50 values between 0.3 and 75.7μM, most probably contributing to the antiproliferative activity.
- Shown to inhibit VEGF-A dependent endothelial cells sprouting with IC50 value of 1.8μM corresponding to its in vitro inhibitory activity against VEGF-R2 protein kinase (IC50=0.8μM).
- Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor.
- Antioxidant. DPPH radical scavenger.
Product References
- Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus: A. Abdel-Lateff, et al.; J. Nat. Prod. 66, 706 (2003)
- Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.: S.S. Ebada, et al.; Bioorg. Med. Chem. 19, 4644 (2011)
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