Anomalin A

CHF 140.00
In stock
AG-CN2-0006-M0011 mgCHF 140.00
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Product Details
Synonyms 2,3,6,8-Tetrahydroxy-1-methylxanthone
Product Type Chemical
Properties
Formula

C14H10O6

MW 274.1
CAS 548740-86-9
Source/Host Chemicals Isolated from marine fungus Arthrinium sp.
Purity Chemicals ≥97% (HPLC)
Appearance Yellowish solid.
Solubility Soluble in 100% ethanol or DMSO.
InChi Key YPBXGIBBOZOVPM-UHFFFAOYSA-N
Smiles [H]C1=C(O)C(O)=C(C)C2=C1OC1=C(C(O)=CC(O)=C1)C2=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antiproliferative agent against selected cancer cell lines. Inhibits protein kinases ALK, ARK5, Aurora-B, AXL, FAK, IGF1-R, MET, PIM1, PLK1, PRK1, SRC, and VEGF-R2 with IC50 values between 0.3 and 75.7μM, most probably contributing to the antiproliferative activity.
  • Shown to inhibit VEGF-A dependent endothelial cells sprouting with IC50 value of 1.8μM corresponding to its in vitro inhibitory activity against VEGF-R2 protein kinase (IC50=0.8μM).
  • Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor.
  • Antioxidant. DPPH radical scavenger.
Product References
  1. Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus: A. Abdel-Lateff, et al.; J. Nat. Prod. 66, 706 (2003)
  2. Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.: S.S. Ebada, et al.; Bioorg. Med. Chem. 19, 4644 (2011)
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