Debromohymenialdisine

CHF 125.00
In stock
AG-CN2-0068-C100100 µgCHF 125.00
More Information
Product Details
Synonyms DBH; DBHA-SKF; SKF 108753
Product Type Chemical
Properties
Formula C11H11N5O2
MW 245.2
CAS 75593-17-8 and 125118-55-0
Source/Host Chemicals Isolated from sponge Axinella carteri.
Purity Chemicals ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO, ethanol or methanol.
Identity Determined by 1H-NMR and MS.
InChi Key JYRJOQGKGMHTOO-VURMDHGXSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Keep under inert gas.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site [1].
  • Cytotoxic and insecticidal [2].
  • G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor [3, 4, 6].
  • Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins [3, 4].
  • MAP kinase kinase 1 (MEK-1) inhibitor [5].
  • Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic [7].
  • Potential anti-Alzheimer agent [7].
Product References
  1. Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats: M. DiMartino, et al.; Inflamm. Res. 44, S123 (1995)
  2. Bioactive alkaloids from the tropical marine sponge Axinella carteri: A. Supriyono, et al.; Z. Naturforsch. C 50, 669 (1995)
  3. Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001)
  4. G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin: N.T. Rundle, et al.; J. Biol. Chem. 276, 48231 (2001)
  5. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002)
  6. G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004)
  7. Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol: Y.F. Song, et al.; Mar. Biotechnol. 13, 868 (2011)
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