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AdipoGen Life Sciences
Cytostatin
380
CHF
CHF 380.00
In stock
AG-CN2-0093-C250250 µgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | 5,6-Dihydro-6-(6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl)-5-methyl-2H-pyran-2-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H32NaO7P |
| MW | 450.4 |
| CAS | 457070-06-3 | 682329-63-1 (free base) |
| Source/Host Chemicals | Isolated from Streptomyces sp. MJ654-NF4. |
| Purity Chemicals | ≥75% (HPLC) |
| Appearance | White to yellowish powder. |
| Solubility | Soluble in methanol, chloroform, ethyl acetate, DMSO or water. |
| Declaration | Manufactured by the Institute of Microbial Chemistry (BIKAKEN). |
| InChi Key | DXWSCXWALSKXSD-ZHCXJCEOSA-M |
| Smiles | [Na+].C\C=C\C=C/C=C\C(O)C(C)C(CCC(C)C1OC(=O)C=CC1C)OP(O)([O-])=O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective protein phosphatase 2A (PP2A) inhibitor [4-7].
- Cell adhesion inhibitor [1]. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin [2].
- Antitumor agent. Antimetastatic [2, 7].
- Apoptosis inducer [3].
Product References
- Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities: M. Amemiya, et al.; J. Antibiot. 47, 536 (1994)
- Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells: T. Masuda, et al.; J. Antibiot. 48, 528 (1995)
- Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin: K. Yamazaki, et al.; J. Antibiot. 48, 1138 (1995)
- Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A: M. Kawada, et al.; Biochim. Biophys. Acta 1452, 209 (1999)
- Small-molecule inhibitors of Ser/Thr protein phosphatases: specificity, use and common forms of abuse: M.R. Swingle, et al.; Methods Mol. Biol. 365, 23 (2007)
- Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and (beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors: M.R. Swingle, et al.; J. Pharmacol. Exp. Ther. 331, 45 (2009)
- Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis: S. Wada, et al.; Cancer Sci. 101, 743 (2010)
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