Asperphenamate

CHF 120.00
In stock
AG-CN2-0171-C250250 µgCHF 120.00
AG-CN2-0171-M0011 mgCHF 360.00
More Information
Product Details
Synonyms Anabellamide; Asjanin; Auranamide; NSC 306231; N-Benzoyl-phenylalanine-2-benzoylamino-3-phenylpropyl ester
Product Type Chemical
Properties
Formula

C32H30N2O4

MW 506.6
CAS 63631-36-7
Source/Host Chemicals Isolated from Aspergillus sp.
Purity Chemicals ≥95% (HPLC)
Appearance White solid.
Solubility Soluble in ethanol, methanol or DMSO.
InChi Key CVULDJMCSSACEO-FQLXRVMXSA-N
Smiles O=C(OC[C@@H](CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1)[C@@H](CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Anticancer compound.
  • Cytotoxic against human breast cancer cells.
  • Induces autophagic cell death in MCF-7 cells.
  • Moderate radical scavenger.
  • Weak acetylcholinesterase (AChE) inhibitor.
  • Shows moderate trypanocidal activity.
Product References
  1. Two metabolites from Aspergillus flavipes: A.M. Clark, et al.; Lloyda 40, 146 (1977)
  2. Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis: P.W. Wu, et al.; Chem. Pharm. Bull. 52, 345 (2004)
  3. A new method for asperphenamate synthesis and its antimicrobial activity evaluation: A.M. Pomini, et al.; Nat. Prod. Res. 20, 537 (2006)
  4. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine: L. Yuane, et al.; Chin. Chem. Lett. 21, 155 (2010)
  5. JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells: Y. Li, et al.; Toxicol. Appl. Pharmacol. 263, 21 (2012)
  6. Two new Penicillium species Penicillium buchwaldii and Penicillium spathulatum, producing the anticancer compound asperphenamate: J.C. Frisvad, et al.; FEMS Microbiol. Lett. 339, 77 (2013)
  7. In vitro acetylcholinesterase activity of peptide derivatives isolated from two species of Leguminosae: C.Q. Alves, et al.; Pharm. Biol. 51, 936 (2013)
  8. Antioxidant activity of compounds isolated from the root woods of Erythrina droogmansiana: A.J.G. Yaya, et al.; Int. J. Pharm. Sci. Drug Res. 6, 160 (2014)
  9. Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae): N.J. Nwodo, et al.; Molecules 19, 5470 (2014)
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