(+)-Catechin . hydrate

CHF 35.00
In stock
AG-CN2-0407-M500500 mgCHF 35.00
AG-CN2-0407-G0011 gCHF 60.00
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Product Details
Synonyms Cianidanol; Cyanidol; Catechol; Catechuic acid; NSC 2819; (+)-3,3',4',5,7-Flavanpentol
Product Type Chemical
Properties
Formula

C15H14O6 . H2O

MW 290.3 . 18.0
Merck Index 14: 1902
CAS 225937-10-0 or 88191-48-4
Source/Host Chemicals Isolated from Uncaria rhynchophylla or Camellia sinensis.
Purity Chemicals ≥95% (NMR)
Appearance Off-white powder.
Solubility Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Identity Determined by 1H-NMR.
InChi Key OFUMQWOJBVNKLR-NQQJLSKUSA-N
Smiles O.O[C@H]1CC2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Keep under inert gas.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
After reconstitution, prepare aliquots and store at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Specific histidine decarboxylase inhibitor [1].
  • Anti-inflammatory. COX-1 inhibitor [2].
  • Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation [3, 6, 9].
  • Antimetastatic and anticancer compound [4, 9, 10, 14, 16, 17].
  • Antiangiogenic [14].
  • Anti-osteoporotic [5].
  • Antibacterial and antifungal [7].
  • Neuroprotective [8]. Mono oxidase B inhibitor [11].
  • Apoptosis and cell cycle arrest inducer [9, 10, 16, 17].
  • JNK phosphorylation inhibitor [12].
  • Antispasmodic [13].
  • Insulin-mimetic [15].
Product References
  1. Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro: H.J. Reimann, et al.; Agents Actions 7, 69 (1977)
  2. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis: Y. Noreen, et al.; Planta Med. 64, 520 (1998)
  3. (+)-Catechin as antioxidant: mechanisms preventing human plasma oxidation and activity in red wines: S.B. Lotito & C.G. Fraga; Biofactors 10, 125 (1999)
  4. Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002) (Review)
  5. Effects of (+)-catechin on the function of osteoblastic cells: E.M. Choi & J.K. Hwang; Biol. Pharm. Bull. 26, 523 (2003)
  6. Dietary supplementation of (+)-catechin protects against UVB-induced skin damage by modulating antioxidant enzyme activities: S.E. Jeon, et al.; Photodermatol. Photoimmunol. Photomed. 19, 235 (2003)
  7. Phytotoxic and antimicrobial activities of catechin derivatives: R. Veluri, et al.; J. Agric. Food Chem. 52, 1077 (2004)
  8. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases: S. Mandel & M.B. Youdim; Free Radic. Biol. Med. 37, 304 (2004) (Review)
  9. A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo: L. Gordon; Haematologica 90, 290 (2005)
  10. (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest: Q. Huang, et al.; J. Pharmacol. Sci. 98, 16 (2005)
  11. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla: W.C. Hou; J. Ethnopharmacol. 100, 216 (2005)
  12. (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006)
  13. Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007)
  14. (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages: C. Guruvayoorappan & G. Kuttan; Innate Immun. 14, 160 (2008)
  15. Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats: P. Daisy, et al.; Phytomedicine 17, 28 (2010)
  16. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis: A.A. Alshatwi; J. Exp. Clin. Cancer Res. 29, 167 (2010)
  17. Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells: A.A. Al-Hazzani & A.A. Alshatwi; Food Chem. Toxicol. 49, 3281 (2011)
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