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AdipoGen Life Sciences
(+)-Catechin . hydrate
40
CHF
CHF 40.00
In stock
AG-CN2-0407-M500500 mgCHF 40.00
AG-CN2-0407-G0011 gCHF 65.00
| Product Details | |
|---|---|
| Synonyms | Cianidanol; Cyanidol; Catechol; Catechuic acid; NSC 2819; (+)-3,3',4',5,7-Flavanpentol |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H14O6 . H2O |
| MW | 290.3 . 18.0 |
| Merck Index | 14: 1902 |
| CAS | 225937-10-0 or 88191-48-4 |
| Source/Host Chemicals | Isolated from Uncaria rhynchophylla or Camellia sinensis. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Off-white powder. |
| Solubility | Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | OFUMQWOJBVNKLR-NQQJLSKUSA-N |
| Smiles | O.O[C@H]1CC2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Keep under inert gas. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Specific histidine decarboxylase inhibitor [1].
- Anti-inflammatory. COX-1 inhibitor [2].
- Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation [3, 6, 9].
- Antimetastatic and anticancer compound [4, 9, 10, 14, 16, 17].
- Antiangiogenic [14].
- Anti-osteoporotic [5].
- Antibacterial and antifungal [7].
- Neuroprotective [8]. Mono oxidase B inhibitor [11].
- Apoptosis and cell cycle arrest inducer [9, 10, 16, 17].
- JNK phosphorylation inhibitor [12].
- Antispasmodic [13].
- Insulin-mimetic [15].
Product References
- Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro: H.J. Reimann, et al.; Agents Actions 7, 69 (1977)
- Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis: Y. Noreen, et al.; Planta Med. 64, 520 (1998)
- (+)-Catechin as antioxidant: mechanisms preventing human plasma oxidation and activity in red wines: S.B. Lotito & C.G. Fraga; Biofactors 10, 125 (1999)
- Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002) (Review)
- Effects of (+)-catechin on the function of osteoblastic cells: E.M. Choi & J.K. Hwang; Biol. Pharm. Bull. 26, 523 (2003)
- Dietary supplementation of (+)-catechin protects against UVB-induced skin damage by modulating antioxidant enzyme activities: S.E. Jeon, et al.; Photodermatol. Photoimmunol. Photomed. 19, 235 (2003)
- Phytotoxic and antimicrobial activities of catechin derivatives: R. Veluri, et al.; J. Agric. Food Chem. 52, 1077 (2004)
- Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases: S. Mandel & M.B. Youdim; Free Radic. Biol. Med. 37, 304 (2004) (Review)
- A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo: L. Gordon; Haematologica 90, 290 (2005)
- (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest: Q. Huang, et al.; J. Pharmacol. Sci. 98, 16 (2005)
- Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla: W.C. Hou; J. Ethnopharmacol. 100, 216 (2005)
- (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006)
- Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007)
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages: C. Guruvayoorappan & G. Kuttan; Innate Immun. 14, 160 (2008)
- Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats: P. Daisy, et al.; Phytomedicine 17, 28 (2010)
- Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis: A.A. Alshatwi; J. Exp. Clin. Cancer Res. 29, 167 (2010)
- Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells: A.A. Al-Hazzani & A.A. Alshatwi; Food Chem. Toxicol. 49, 3281 (2011)
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