Vitexin

Specifications / Handling

More Information
Product Details
Synonyms	8-Glucopyranosylapigenin; 8-Glucosylapigenin; Orientoside
Product Type	Chemical
Properties
Formula	C₂₁H₂₀O₁₀
MW	432.4
CAS	3681-93-4
RTECS	DJ2984000
Source/Host Chemicals	Isolated from Crataegus pinnatifida.
Purity Chemicals	≥98% (HPLC)
Appearance	Yellow crystalline powder.
Solubility	Soluble in DMSO or dimethylformamide.
InChi Key	SGEWCQFRYRRZDC-VPRICQMDSA-N
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=C2OC(=CC(=O)C2=C(O)C=C1O)C1=CC=C(O)C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

α-Glucosidase inhibitor [3, 8].
Antioxidant [1, 3].
HIF-1 α inhibitor [2].
Anti-metastatic [2, 13].
Apoptosis inducer [4, 9, 13].
Tumor suppressor [4, 9].
Adipogenesis inhibitor [5].
Inhibits SIRT6 in vitro [6].
Inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K [7].
Cardioprotective [10].
Anti-inflammatory [11].
Shows analgesic effect by targeting TRPV1 channel activity [11].
Neuroprotective. Inhibits NMDA receptors [12].

Product References

The isolation and antioxidative effects of vitexin from Acer palmatum: J.H. Kim, et al.; Arch. Pharm. Res. 28, 195 (2005)
Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells: H.J. Choi, et al.; Mol. Cells 22, 291 (2006)
Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity: M. Shibano, et al.; J. Nat. Med. 62, 349 (2008)
Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth: Y. Zhou, et al.; Clin. Cancer Res. 15, 5161 (2009)
Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells: J. Kim, et al.; Phytother. Res. 24, 1543 (2010)
Synthesis and characterization of SIRT6 protein coated magnetic beads: identification of a novel inhibitor of SIRT6 deacetylase from medicinal plant extracts: M. Yasuda, et al.; Anal. Chem. 83, 7400 (2011)
Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K: K.M. Helms, et al.; Nat. Prod. Commun. 6, 1411 (2011)
Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition: C.Y. Choo, et al.; J. Ethnopharmacol. 142, 776 (2012)
Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway: C.Y. Lee, et al.; Oncol. Rep. 28, 1883 (2012)
Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways: C.C. Lu, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 386, 747 (2013)
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines: S.M. Borghi, et al.; J. Nat. Prod. 76, 1141 (2013)
The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells: S.H. Yang, et al.; Phytother. Res. 27, 1154 (2013)
Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons: L. Yang, et al.; Mol. Cell Biochem. 386, 251 (2014)
A review on the pharmacological effects of vitexin and isovitexin: M. He, et al.; Fitoterapia 115, 74 (2016)
Molecular targets of vitexin and isovitexin in cancer therapy: a critical review: K. Ganesan & B. Xu; Ann. N. Y. Acad. Sci. 1401, 102 (2017)
Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells: M. Bhardwaj, et al.; Oncotarget 9, 3278 (2018)

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