Triptolide

Specifications / Handling

More Information
Product Details
Synonyms	PG 490; NSC163062
Product Type	Chemical
Properties
Formula	C₂₀H₂₄O₆
MW	360.4
CAS	38748-32-2
RTECS	YK7751000
Source/Host Chemicals	Isolated from Tripterygium sp.
Purity Chemicals	≥98% (HPLC)
Appearance	Crystalline solid.
Solubility	Soluble in DMSO. Sparingly soluble in ethanol.
Identity	Determined by ¹H-NMR.
InChi Key	DFBIRQPKNDILPW-KTGKZQHOSA-N
Smiles	CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3CC3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Keep under inert gas. Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Potent immunosuppressant with anti-inflammatory and antitumor properties.
Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators.
Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH).
Human dCTP pyrophosphatase 1 inhibitor.
Interferes with a number of transcription factors including p53, NF-κB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1).
Shown to inhibit aromatase activity.
Shows antifertility activity and antipolycystic kidney disease effects.

Product References

Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii: S.M. Kupchan, et al.; JACS 94, 7194 (1972)
Triptolide: a potential male contraceptive: Y. Lue, et al.; J. Androl. 19, 479 (1998)
Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology 40, 139 (1998)
Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes: H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000)
Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F: B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review)
Triptolide inhibits the growth and metastasis of solid tumors: S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003)
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006)
Triptolide alters mitochondrial functions: Y. Su, et al.; Adv. Exp. Med. Biol. 599, 139 (2007)
Triptolide functions as a potent angiogenesis inhibitor: M.F. He, et al.; Int. J. Cancer 126, 266 (2010)
Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors: S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011)
RNA polymerase - an important molecular target of triptolide in cancer cells: J. Pan; Cancer Lett. 292, 149 (2010) (Review)
Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways: N. Mujumdar, et al.; Gastroenterol. 139, 598 (2010)
Triptolide and its expanding multiple pharmacological functions: Q. Liu; Int. Immunopharmacol. 11, 377 (2011) (Review)
XPB, a subunit of TFIIH, is a target of the natural product triptolide: D.V. Titov, et al.; Nat. Chem. Biol. 7, 182 (2011)
Triptolide directly inhibits dCTP pyrophosphatase: T.W. Corson, et al.; Chembiochem 12, 1767 (2011)
Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II): Y. Wang, et al.; PLoS One 6, e23993 (2011)
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms: Z.L. Zhou, et al.; Nat. Prod. Rep. 29, 457 (2012)
Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells: J. Zhang, et al.; Arzneimittelforschung 61, 727 (2011)
TAB1: a target of triptolide in macrophages: Y. Lu, et al.; Chem. Biol. 21, 246 (2014)
Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway: H. Shao, et al.; Exp. Ther. Med. 8, 505 (2014)
Triptolide Induces Cell Damage in Lipopolysaccharide (LPS)-Treated Macrophages in an LPS-Signaling Cascade-Dependent Manner: K. Kohama, et al.; J. Cytokine Biol. 2, (2017)
Incorporation of CENP-A/CID into centromeres during early Drosophila embryogenesis does not require RNA polymerase II-mediated transcription: S. Gosh & C.F. Lehner; Chromosoma, ahead of print (2022)

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