AdipoGen Life Sciences


CHF 160.00
In stock
AG-CN2-0459-M01010 mgCHF 160.00
AG-CN2-0459-M05050 mgCHF 480.00
More Information
Product Details
Synonyms ISL; GU 17; 4,2',4'-Trihydroxychalcone
Product Type Chemical


MW 256.3
CAS 961-29-5
Source/Host Chemicals Synthetic. Originally isolated from Glycyrrhiza sp.
Purity Chemicals ≥97% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO, methanol or ethanol.
Smiles OC1=CC=C(\C=C\C(=O)C2=C(O)C=C(O)C=C2)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer.
  • Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor.
  • Antioxidant and antibacterial.
  • AMPK-mediated GSK3β inhibitor.
  • Anti-inflammatory. Inhibits translocation and activation of NF-κB by blocking phosphorylation and subsequent degradation of IκBα.
  • Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling.
  • NLRP3 inflammasome activation inhibitor. Inhibits NLRP3-activated ASC oligomerization.
  • Can block the NLRP3 inflammasome at both the priming step and the activation step.
  • H(2) histamine receptor signaling inhibitor.
  • Anti-diabetic. Antihyperglycemic.
  • Aldose reductase inhibitor.
  • Vasorelaxant. Soluble guanylyl cyclase activator.
  • GABAA receptor positive allosteric modulator.
  • Potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor.
  • Shown to inhibit breast cancer stem cells through WIF1 demethylation.
  • Shows outstanding matrix properties for MALDI-TOF-MS analysis of oligosaccharides.
  • Antiviral
  • Reduces lung inflammation
  • Activator of Bone Morphogenetic Protein BMP signaling.
Product References
  1. The potent anti-tumor-promoting agent isoliquiritigenin: S. Yamamoto, et al.; Carcinogenesis 12, 317 (1991)
  2. Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice: M. Tawata, et al.; Eur. J. Pharmacol. 212, 87 (1992)
  3. Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta: S.M. Yu & S.C. Kuo; Br. J. Pharmacol. 114, 1587 (1995)
  4. Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation: J. Vaja, et al.; Free Radic. Biol. Med. 23, 302 (1997)
  5. Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells: Y.L. Hsu, et al.; Planta Med. 71, 130 (2005)
  6. Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells: Y.L. Hsu, et al.; Life Sci. 77, 279 (2005)
  7. Isoliquiritigenin selectively inhibits H(2) histamine receptor signalling: D.C. Kim, et al.; Mol. Pharmacol. 70, 493 (2006)
  8. Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells: S. Kumar, et al.; Biochem. Pharmacol. 73, 1602 (2007)
  9. Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages: S.J. Park, et al.; Mol. Cells 28, 365 (2009)
  10. AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress: S.H. Choi, et al.; Biochem. Pharmacol. 79, 1352 (2010)
  11. Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1: S.J. Park & H.S. Youn; J. Agric. Food Chem. 58, 4701 (2010)
  12. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects: S. Cho, et al.; BBRC 413, 637 (2011)
  13. Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides: H. Yang, et al.; Anal. Chim. Acta 70, 45 (2011)
  14. Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease: C. Muanprasat, et al.; J. Pharmacol. Sci. 118, 82 (2012)
  15. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway: Z. Wang, et al.; PLoS One 8, e68566 (2013)
  16. In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin: T. Gaur, et al.; Phytomedicine 21, 415 (2014)
  17. MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin: Z. Wang, et al.; Oncotarget 5, 7013 (2014)
  18. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation: H. Honda, et al.; J. Leukoc. Biol. 96, 1087 (2014)
  19. Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation: N. Wang, et al.; Oncotarget 6, 9854 (2015)
  20. A Review: The Pharmacology of Isoliquiritigenin: F. Peng, et al.; Phytother. Res. 29, 969 (2015)
  21. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection: H. Traboulsi, et al.; Antimicrob. Agents Chemother. 59, 6317 (2015)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.