Procyanidin A2

CHF 60.00
In stock
AG-CN2-0486-M0011 mgCHF 60.00
AG-CN2-0486-M0055 mgCHF 180.00
AG-CN2-0486-M02525 mgCHF 630.00
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Product Details
Synonyms (+)-Epicatechin-(4β-8,2β-O-7)-epicatechin; PCA2; Proanthocyanidin A2; PA2; Procyanidol A2; Procyanidin dimer A2
Product Type Chemical
Properties
Formula C30H24O12
MW 576.5
CAS 41743-41-3
Source/Host Chemicals Isolated from grape seeds (Vitis vinifera L).
Purity Chemicals ≥95% (NMR)
Appearance Pale pink solid.
Solubility Soluble in DMSO, 100% ethanol or methanol. Sparingly soluble in water (0.1 mg/ml).
Identity Determined by 1H-NMR.
InChi Key NSEWTSAADLNHNH-LSBOWGMISA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from moisture and oxygen.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • A-Type proanthocyanidine.
  • Potent antioxidant. Free radical scavenger and lipid peroxidation inhibitor.
  • Potent low-density lipoprotein (LDL) oxidation inhibitor.
  • Antidiabetic. Prevents islet cell apoptosis, hyperglycemia and type 2 diabetes through it's antioxidant properties.
  • Antibacterial agent.
  • Antiviral. Shown to inhibit viral replication of canine distemper virus (CDV).
  • Glycosyltransferase B (GTFB) inhibitor.
Product References
  1. Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006)
  2. Influence of cranberry phenolics on glucan synthesis by glucosyltransferases and Streptococcus mutans acidogenicity: S. Gregoire, et al.; J. Appl. Microbiol. 103, 1960 (2007)
  3. Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo: H. Koo, et al.; Caries Res. 44, 116 (2010)
  4. Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties: T.O. Idowu, et al.; Phytochemistry 71, 2092 (2010)
  5. Inhibition of viral RNA synthesis in canine distemper virus infection by proanthocyanidin A2: L. Gallina, et al.; Antiviral Res. 92, 447 (2011)
  6. Flavonoids from Lindera glauca blume as low-density lipoprotein oxidation inhibitors: G.W. Huh, et al.; Nat. Prod. Res. 28, 831 (2014)
  7. Procyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation: H.J. Park, et al.; Arch. Pharm. Res. 37, 1403 (2014)
  8. Chemical composition, antioxidant and antinociceptive properties of Litchi chinensis leaves: R.C. Castellain, et al.; J. Pharm. Pharmacol. 66, 1796 (2014)
  9. Preventive effects of procyanidin A2 on glucose homeostasis, pancreatic and duodenal homebox 1, and glucose transporter 2 gene expression disturbance induced by bisphenol A in male mice: A. Ahangarpour, et al.; J. Physiol. Pharmacol. 67, 243 (2016)
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