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Antimycobacterial and antibacterial agent. Exerts its antibacterial effect by inhibiting enzyme BCG 3185c, a suspected dioxygenase thereby disrupting bacterial homeostasis.
Associated with contractive responses of smooth muscles and inhibition of Na+/K+ ATPase.
Cytotoxic/Antineoplastic agent. Found to exhibit inhibitory activity against several cancer cell lines, including the drug resistant renal cancer cell line (ACHN).
Suppressor of RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1, NF-κB and ERK.
Antiprotozoal compound.
Product References
Agelasine-A -B, -C and -D, novel bicyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on Na,K-ATPase isolated from the Okinawian sea sponge Agelas sp: H. Nakamura, et al.; Tetrahedron Lett. 25, 2989 (1984)
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities: A. Vik, et al.; J. Nat. Prod. 69, 381 (2006)
Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a beta-cyclocitral derived substituent: A. Proszenyak, et al.; Arch. Pharm. 340, 625 (2007)
Antifouling activity of the sponge metabolite agelasine D and synthesised analogs on Balanus improvisus: M. Sjoegren, et al.; Biofouling 24, 251 (2008)
Screening of Agelasine D and Analogs for Inhibitory Activity against Pathogenic Protozoa; Identification of Hits for Visceral Leishmaniasis and Chagas Disease: A. Vik, et al.; Molecules 14, 279 (2009)
From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two Indonesian Agelas sponges: T. Hertiani, et al.; Bioorg. Med. Chem. 18, 1297 (2010)
Synthesis and biological activities of marine terpene-adenine hybrids and synthetic analogs: L.-L. Gundersen; Phytochem. Rev. 12, 467 (2013) (Review)
Identification of the target protein of agelasine D, a marine sponge diterpene alkaloid, as an anti-dormant mycobacterial substance: M. Arai, et al.; Chembiochem. 15, 117 (2014)
Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB: M.R. Kang, et al.; Mar. Drugs 12, 5643 (2014)
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