AdipoGen Life Sciences

BRP [BRINP2-related Peptide]

As low as CHF 70.00

In stock

Only %1 left

AG-CP3-0048-M0055 mgCHF 70.00

AG-CP3-0048-M02525 mgCHF 210.00

NEW

BULK available!
Research Use Only (RUO). NOT ALLOWED FOR USE IN HUMANS.

More Information
Product Details
Synonyms	H-THRILRRLFNLC-NH2
Product Type	Chemical
Properties
Formula	C₆₈H₁₁₇N₂₅O₁₄S
MW	1540.9
Sequence	H-Thr-His-Arg-Ile-Leu-Arg-Arg-Leu-Phe-Asn-Leu-Cys-NH2
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥95% (HPLC)
Appearance	White lyophilized powder.
Solubility	Soluble in water (1mg/ml).
InChi Key	HMJIRJDBVYKLDC-KVBBLKIJSA-N
Smiles	CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CS)=O)CC(C)C)=O)CC(N)=O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)N)=O)CC2=CNC=N2)=O)CCCNC(N)=N)=O)C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Description

BRP (BRINP2-related peptide) is a 12-amino acid peptide, which was discovered through Peptide Predictor, a computational-functional approach based on prohormone convertase (PCSK) prohormone processing. BRP is generated by the cleavage of the 78-kDa secreted parent protein BRINP2 by enzymes such as PCSK1. The C-terminal amidation of BRP is critical for bioactivity. In mice, humans and pigs, BRINP2 is predominantly expressed in the brain.
When administered pharmacologically, BRP reduces food intake and exhibits anti-obesity effects in mice and pigs. BRP administration triggers central FOS activation and acts independently of leptin, GLP-1 receptor (GLP1R) and melanocortin 4 receptor (MC4R). Instead, it activates the central CREB-FOS signaling pathway, specifically by activating some regions of the hypothalamus. BRP does not cause changes in pancreatic activity and does not affect blood glucose levels and insulin secretion. It also does not induce nausea or aversion, unlike GDF15, showing certain advantages in improving metabolism.

Product References

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide: L. Coassolo, et al.; Nature (Epub ahead of print) (2025)

Call	+41 61 926 6040
Fax	+41 61 926 6049