Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
H-89 . dihydrochloride
30
CHF
CHF 30.00
In stock
AG-CR1-0002-M0011 mgCHF 30.00
AG-CR1-0002-M0055 mgCHF 55.00
AG-CR1-0002-M02525 mgCHF 220.00
| Product Details | |
|---|---|
| Synonyms | N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H20BrN3O2S . 2HCl |
| MW | 446.4 . 72.9 |
| CAS | 130964-39-5 | 127243-85-0 (free base) |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (50mg/ml), DMF (20mg/ml), ethanol (1mg/ml) or methanol (1mg/ml). Slightly soluble in water. |
| Other Product Data |
Stock solutions are stable for at least 3-4 weeks when stored at +4°C. We recommend using a fresh solution each day. |
| InChi Key | ZKZXNDJNWUTGDK-NSCUHMNNSA-N |
| Smiles | BrC1=CC=C(C=CCNCCNS(=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor [1-3].
- Protein kinase Cμ (PKCμ) inhibitor [4].
- Ca2+/calmodulin-dependent protein kinase II inhibitor [2].
- Casein kinase I inhibitor [2].
- Myosin light chain kinase (MLCK) inhibitor [2].
- Apoptosis enhancer [5].
- Tool to study protein crystal structure-inhibitor interactions [6].
- Rho kinase inhibitor [7].
- Cell proliferation inhibitor [8].
- Review [9].
- Chondrogenesis inducer
Product References
- Polyamines differentially inhibit cyclic AMP-dependent protein kinase-mediated phosphorylation in the brain of the tobacco hornworm, Manduca sexta.: W.L. Combest et al.; J. Neurochem. 51, 1581 (1988)
- Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12: T. Chijiwa et al.; J. Biol. Chem. 265, 5267 (1990)
- A selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-bromocinnamyl(amino)ethyl]-5- isoquinolinesulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells: C.C. Geilen et al.; FEBS Lett. 309, 381 (1992)
- Characterization of activators and inhibitors of protein kinase C mu: F.J. Johannes et al.; Eur. J. Biochem. 227, 303 (1995)
- Protein kinase A inhibitors enhance radiation-induced apoptosis: D. Findik et al.; J. Cell Biochem. 57, 12 (1995)
- Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh et al.; J. Biol. Chem. 271, 26157 (1996)
- The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase: J. Leemhuis, et al.; J. Pharmacol. Exp. Ther. 300, 1000 (2002)
- H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation: D. Umeda, et al.; Eur. J. Pharmacol. 590, 61 (2008)
- The many faces of H89: a review: A. Lochner & J.A. Moolman; Cardiovasc. Drug Rev. 24, 261 (2006)
- Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells: M. Mushtaq, et al.; Oncotarget 8, 64907 (2017)
- Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress: M. Holczer, et al.; Oxid. Med. Cell. Longev. 6721530 (2018)
- Silibinin promotes melanogenesis through the PKA and p38 MAPK signaling pathways in melanoma cells: T. Uto, et al.; Biomed. Res. 43, 31 (2022)