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AdipoGen Life Sciences
MTEP
100
CHF
CHF 100.00
In stock
AG-CR1-0022-M0055 mgCHF 100.00
AG-CR1-0022-M02525 mgCHF 400.00
| Product Details | |
|---|---|
| Synonyms | 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H8N2S |
| MW | 200.3 |
| CAS | 329205-68-7 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Light yellow solid. |
| Solubility | Soluble in DMSO, 100% ethanol or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | NRBNGHCYDWUVLC-UHFFFAOYSA-N |
| Smiles | CC1=NC(=CS1)C#CC1=CC=CN=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective antagonist for mGluR5 [1, 2].
- 5-fold higher anxiolytic activity than MPEP [3].
- Antidepressant [4].
- Neuroprotective [5].
- Produces antiparkinsonian-like effects in rats [6].
Product References
- 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003)
- Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004)
- Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006)
- Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005)
- Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005)
- MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005)