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AdipoGen Life Sciences
Sirtinol
35
CHF
CHF 35.00
In stock
AG-CR1-0055-M0011 mgCHF 35.00
AG-CR1-0055-M0055 mgCHF 70.00
AG-CR1-0055-M02525 mgCHF 210.00
| Product Details | |
|---|---|
| Synonyms | Sir Two Inhibitor Naphthol; 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H22N2O2 |
| MW | 394.5 |
| CAS | 410536-97-9 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white to yellow solid. |
| Solubility | Soluble in DMSO, 100% ethanol or dimethyl formamide. |
| Other Product Data |
Relatively unstable in aqueous solution, especially at acidic pH. |
| InChi Key | UXJFDYIHRJGPFS-WPWMEQJKSA-N |
| Smiles | CC(NC(=O)C1=C(C=CC=C1)\N=C\C1=C(O)C=CC2=C1C=CC=C2)C1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Specific cell permeable SIRT1 (sirtuin 1) inhibitor [1, 2].
- Senescence-like growth arrest inducer [3].
- Platelet aggregation inhibitor [4].
- Apoptosis inducer [5].
Product References
- Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001)
- Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005)
- Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006)
- A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009)
- SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010)
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