AdipoGen Life Sciences


CHF 50.00
In stock
AG-CR1-3514-M0011 mgCHF 50.00
AG-CR1-3514-M0055 mgCHF 115.00
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Product Details
Synonyms N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Product Type Chemical


MW 480.0
CAS 329196-48-7
Purity Chemicals ≥95% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO, ethanol or chloroform.
Identity Determined by 1H-NMR.
Smiles CCOC1=CC(=CC(OCC)=C1OCC)C(=O)NC1=CC(C2=NC3=C(N2)C=CC=C3)=C(Cl)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Sonic hedgehog (Shh) signaling pathway modulator.
  • Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo.
  • SAG activity (Prod. Nr. AG-CR1-3506) inhibitor.
  • Gli1 reporter gene expression inhibitor.
  • Suppresses the Shh-dependent translocation of Smo to the primary cilium.
  • Potential tumor growth blocker.
Product References
  1. Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002)
  2. Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review)
  3. Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009)
  4. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009)
  5. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. Büttner, et al.; Bioorg. Med. Chem. 17, 4943 (2009)
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