AdipoGen Life Sciences


CHF 35.00
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AG-CR1-3515-M0011 mgCHF 35.00
AG-CR1-3515-M0055 mgCHF 95.00
AG-CR1-3515-M02525 mgCHF 285.00
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Product Details
Synonyms (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
Product Type Chemical


MW 351.5
CAS 872573-93-8
Purity Chemicals ≥95% (NMR)
Appearance Brown solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
Smiles O=C1N=C(NCC2=CC=CS2)S\C1=C/C1=CC2=C(C=C1)N=CC=C2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A) [1-3, 5].
  • Potential anti-cancer compound [1, 8].
  • Cell cycle arrest inducer at G1, S and G2/M [2, 7] .
  • Apoptosis inducer in embryonic stem cells [4].
  • Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines [6].
  • Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387 [8, 9].
  • Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards [9].
Product References
  1. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1: L.T. Vassilev, et al.; PNAS 103, 10660 (2006)
  2. Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1: L.T. Vassilev; Cell Cycle 5, 2555 (2006)
  3. Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle: L. Krasinska, et al.; Cell Cycle 7, 1702 (2008)
  4. Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity: Z. Ullah, et al.; Genes Dev. 22, 3024 (2008)
  5. Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis: H.T. Ma, et al.; Mol. Cell Biol. 29, 6500 (2009)
  6. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML: K. Kojima, et al.; Cancer Sci. 100, 1128 (2009)
  7. Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells: C. El Boustany, et al.; Cell Calcium 47, 350 (2010)
  8. Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells: N.N. Kreis, et al.; Oncogene 29, 5591 (2010)
  9. Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity: Y. Matthess, et al.; Mol. Cell Biol. 30, 5726 (2010)
  10. Re-Evaluating the Relevance of the Oxygen–Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition: T. D'Aes, et al.; Int. J. Mol. Sci. 24, 7009 (2023)
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