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AdipoGen Life Sciences
RO-3306
35
CHF
CHF 35.00
In stock
AG-CR1-3515-M0011 mgCHF 35.00
AG-CR1-3515-M0055 mgCHF 95.00
AG-CR1-3515-M02525 mgCHF 285.00
| Product Details | |
|---|---|
| Synonyms | (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H13N3OS2 |
| MW | 351.5 |
| CAS | 872573-93-8 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Brown solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | XOLMRFUGOINFDQ-YBEGLDIGSA-N |
| Smiles | O=C1N=C(NCC2=CC=CS2)S\C1=C/C1=CC2=C(C=C1)N=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A) [1-3, 5].
- Potential anti-cancer compound [1, 8].
- Cell cycle arrest inducer at G1, S and G2/M [2, 7] .
- Apoptosis inducer in embryonic stem cells [4].
- Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines [6].
- Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387 [8, 9].
- Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards [9].
Product References
- Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1: L.T. Vassilev, et al.; PNAS 103, 10660 (2006)
- Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1: L.T. Vassilev; Cell Cycle 5, 2555 (2006)
- Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle: L. Krasinska, et al.; Cell Cycle 7, 1702 (2008)
- Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity: Z. Ullah, et al.; Genes Dev. 22, 3024 (2008)
- Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis: H.T. Ma, et al.; Mol. Cell Biol. 29, 6500 (2009)
- Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML: K. Kojima, et al.; Cancer Sci. 100, 1128 (2009)
- Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells: C. El Boustany, et al.; Cell Calcium 47, 350 (2010)
- Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells: N.N. Kreis, et al.; Oncogene 29, 5591 (2010)
- Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity: Y. Matthess, et al.; Mol. Cell Biol. 30, 5726 (2010)
- Re-Evaluating the Relevance of the Oxygen–Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition: T. D'Aes, et al.; Int. J. Mol. Sci. 24, 7009 (2023)