Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Inosine
25
CHF
CHF 25.00
In stock
AG-CR1-3554-M100100 mgCHF 25.00
AG-CR1-3554-M500500 mgCHF 40.00
AG-CR1-3554-G0011 gCHF 65.00
| Product Details | |
|---|---|
| Synonyms | 9-β-D-Ribofuranosylhypoxanthine; NSC 20262; Hypoxanthine 9-β-D-ribofuranoside |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H12N4O5 |
| MW | 268.2 |
| CAS | 58-63-9 |
| RTECS | NM7460000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water (10mg/ml) or DMSO (10mg/ml). |
| InChi Key | UGQMRVRMYYASKQ-KQYNXXCUSA-N |
| Smiles | O[C@H]([C@@H](CO)O1)[C@@H](O)[C@@H]1N2C=NC3=C2NC=NC3=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at +20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Inosine, an intermediate in purine metabolism, consists of hypoxanthine and ribose. It is an inert purine nucleoside formed by breakdown of adenosine (deamination, known as A-to-I editing that occurs in tRNA and mRNA) or also is generated by the action of 5'-nucleotidase on inosine monophosphate (IMP).
- Inosine has neuroprotective, cardioprotective, immunomodulatory, anti-tumor and anti-inflammatory effects in different experimental models.
- Inosine functions are mediated in receptor-dependent or-independent manners. The receptor-mediated function of inosine is thought to be related to adenosine receptor family members including A1, A2A, A2B, and A3 G-protein coupled receptors. It is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
- Inosine is released from brown adipocytes (BAs) upon stress. Inosine activates purinergic P1 receptors, triggering BA activation and white adipocyte browning. Consequently, inosine increases whole-body energy consumption and alleviates diet-induced obesity in mice. Inosine and other closely related purines might be a novel approach to tackle obesity and associated metabolic disorders by enhancing energy expenditure. Inosine is a potent activator of brown adipose tissue and energy homeostasis.
Product References
- The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias: A.A. Welihinda, et al.; Cell Signal. 28, 552 (2016)
- Adenosine-to-inosine RNA editing in neurological development and disease: Y. Yang, et al.; RNA Biol. 18, 999 (2021) (Review)
- Inosine in Neurodegenerative Diseases: From the Bench to the Bedside: M.S. Basile, et al.; Molecules 27, 4644 (2022) (Review)
- Inosine: A bioactive metabolite with multimodal actions in human diseases: I.S. Kim, et al.; Front. Pharmacol. 13, 1043970 (2022) (Review)
- Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine: B. Niemann, et al.; Nature 609, 361 (2022)
- Inosine, gut microbiota, and cancer immunometabolism: E. Samami, et al.; Am. J. Physiol. Endocrinol. Metab. 324, E1 (2023) (Review)
- Inosine: novel activator of brown adipose tissue and energy homeostasis: A. Pfeifer, et al.; Trends Cell Biol. (epub ahead of print) (2023) (Review)