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AdipoGen Life Sciences
Inosine
25
CHF
CHF 25.00
In stock
AG-CR1-3554-M100100 mgCHF 25.00
AG-CR1-3554-M500500 mgCHF 40.00
AG-CR1-3554-G0011 gCHF 65.00
| Product Details | |
|---|---|
| Synonyms | 9-β-D-Ribofuranosylhypoxanthine; NSC 20262; Hypoxanthine 9-β-D-ribofuranoside |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H12N4O5 |
| MW | 268.2 |
| CAS | 58-63-9 |
| RTECS | NM7460000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water (10mg/ml) or DMSO (10mg/ml). |
| InChi Key | UGQMRVRMYYASKQ-KQYNXXCUSA-N |
| Smiles | O[C@H]([C@@H](CO)O1)[C@@H](O)[C@@H]1N2C=NC3=C2NC=NC3=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at +20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
- Inosine, an intermediate in purine metabolism, consists of hypoxanthine and ribose. It is an inert purine nucleoside formed by breakdown of adenosine (deamination, known as A-to-I editing that occurs in tRNA and mRNA) or also is generated by the action of 5'-nucleotidase on inosine monophosphate (IMP).
- Inosine has neuroprotective, cardioprotective, immunomodulatory, anti-tumor and anti-inflammatory effects in different experimental models.
- Inosine functions are mediated in receptor-dependent or-independent manners. The receptor-mediated function of inosine is thought to be related to adenosine receptor family members including A1, A2A, A2B, and A3 G-protein coupled receptors. It is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
- Inosine is released from brown adipocytes (BAs) upon stress. Inosine activates purinergic P1 receptors, triggering BA activation and white adipocyte browning. Consequently, inosine increases whole-body energy consumption and alleviates diet-induced obesity in mice. Inosine and other closely related purines might be a novel approach to tackle obesity and associated metabolic disorders by enhancing energy expenditure. Inosine is a potent activator of brown adipose tissue and energy homeostasis.
Product References
- The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias: A.A. Welihinda, et al.; Cell Signal. 28, 552 (2016)
- Adenosine-to-inosine RNA editing in neurological development and disease: Y. Yang, et al.; RNA Biol. 18, 999 (2021) (Review)
- Inosine in Neurodegenerative Diseases: From the Bench to the Bedside: M.S. Basile, et al.; Molecules 27, 4644 (2022) (Review)
- Inosine: A bioactive metabolite with multimodal actions in human diseases: I.S. Kim, et al.; Front. Pharmacol. 13, 1043970 (2022) (Review)
- Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine: B. Niemann, et al.; Nature 609, 361 (2022)
- Inosine, gut microbiota, and cancer immunometabolism: E. Samami, et al.; Am. J. Physiol. Endocrinol. Metab. 324, E1 (2023) (Review)
- Inosine: novel activator of brown adipose tissue and energy homeostasis: A. Pfeifer, et al.; Trends Cell Biol. (epub ahead of print) (2023) (Review)