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AdipoGen Life Sciences
GANT61
60
CHF
CHF 60.00
In stock
AG-CR1-3561-M0011 mgCHF 60.00
AG-CR1-3561-M0055 mgCHF 130.00
| Product Details | |
|---|---|
| Synonyms | NSC 136476; 2,2’-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H35N5 |
| MW | 429.6 |
| CAS | 500579-04-4 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or ethanol. |
| InChi Key | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
| Smiles | CN(C)C1=CC=CC=C1CN1CCCN(CC2=C(C=CC=C2)N(C)C)C1C1=CC=NC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription [1].
- Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU [1].
- Displays antiproliferative and antitumor activity in vitro and in vivo [1, 2 , 3, 4, 5].
- Apoptosis inducer [1, 2 , 3, 4, 5].
Product References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007)
- Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells: P. Desch, et al.; Oncogene 29, 4885 (2010)
- Hedgehog signaling drives cellular survival in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 1092 (2011)
- HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. M. Yan, et al.; Oral Oncol. 47, 504 (2011)
- Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 5904 (2011)
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