AdipoGen Life Sciences


CHF 60.00
In stock
AG-CR1-3561-M0011 mgCHF 60.00
AG-CR1-3561-M0055 mgCHF 130.00
More Information
Product Details
Synonyms NSC 136476; 2,2’-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine
Product Type Chemical


MW 429.6
CAS 500579-04-4
Purity Chemicals ≥98%
Appearance White to off-white solid.
Solubility Soluble in DMSO or ethanol.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription [1].
  • Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU [1].
  • Displays antiproliferative and antitumor activity in vitro and in vivo [1, 2 , 3, 4, 5].
  • Apoptosis inducer [1, 2 , 3, 4, 5].
Product References
  1. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007)
  2. Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells: P. Desch, et al.; Oncogene 29, 4885 (2010)
  3. Hedgehog signaling drives cellular survival in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 1092 (2011)
  4. HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. M. Yan, et al.; Oral Oncol. 47, 504 (2011)
  5. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 5904 (2011)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.