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AdipoGen Life Sciences
IWR-1-endo
110
CHF
CHF 110.00
In stock
AG-CR1-3581-M0055 mgCHF 110.00
| Product Details | |
|---|---|
| Synonyms | 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H19N3O3 |
| MW | 409.4 |
| CAS | 1127442-82-3 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or DMF. |
| Other Product Data |
Note: Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, dissolve first in DMSO and then dilute with the aqueous buffer of choice. Solubility in a 1:3 solution of DMSO:PBS (pH 7.2) (~0.25 mg/ml). It is recommended to use fresh aqueous solutions and not to store them for more than one day. |
| InChi Key | ZGSXEXBYLJIOGF-UBYGHTOYDO |
| Smiles | [H][C@@]12C3CC(C=C3)[C@]1([H])C(=O)N(C2=O)C1=CC=C(C=C1)C(=O)NC1=C2N=CC=CC2=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and reversible cell permeable Wnt pathway signaling inhibitor [1, 2, 4, 5].
- Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3β.
- Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay) [3, 6].
Product References
- Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer: B. Chen, et al.; Nat. Chem. Biol. 5, 100 (2009)
- Structure-activity relationship studies of small-molecule inhibitors of Wnt response: J. Lu, et al.; Bioorg. Med. Chem. Lett. 19, 3825 (2009)
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling: S.M. Huang, et al.; Nature 461, 614 (2009)
- Wnt signaling is required for early development of zebrafish swimbladder: A. Yin, et al.; PLoS One 6, e18431 (2011)
- Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants: A. Yin, et al.; Biochim. Biophys. Acta 1823, 236 (2012)
- Structural basis of selective inhibition of human tankyrases: M. Narwal, et al.; J. Med. Chem. 55, 1360 (2012)