Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Loxoribine
40
CHF
CHF 40.00
In stock
AG-CR1-3584-M0055 mgCHF 40.00
AG-CR1-3584-M02525 mgCHF 120.00
| Product Details | |
|---|---|
| Synonyms | 7-Allyl-8-oxoguanosine; RWJ 21757 |
| Product Type | Chemical |
| Properties | |
| Formula |
C13H17N5O6 |
| MW | 339.3 |
| CAS | 121288-39-9 |
| Purity Chemicals | ≥97% |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (30mg/ml) or water (10mg/ml). |
| InChi Key | VDCRFBBZFHHYGT-HKPXRNTQDL |
| Smiles | NC1=NC2=C(N(CC=C)C(=O)N2[C@@H]2O[C@H](CO)C(O)[C@@H]2O)C(=O)N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Guanosine analog derivatized at position N7 and C8 [1].
- Very potent immunostimulatory compound that increases cytokine production [2-5].
- Antitumor and antiviral activity compound [5, 6, 7, 12].
- Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) [7-10].
- Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8 [11].
- Induces autophagy and autophagy-induced cell death in Caco-2 cells [12].
- Shows adjuvant activity to increase the effectiveness of vaccines [4].
- Inducer of Hunner-Type Interstitial Cystitis (HIC).
Product References
- Substituted guanine ribonucleosides as B cell activators: S. Gupta, et al.; Clin. Immunol. Immunopathol. 61, 21 (1991)
- In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine): B.L. Pope, et al.; Int. J. Immunopharmacol. 14, 1375 (1992)
- Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2: B.L. Pope, et al.; J. Immunol. 151, 3007 (1993)
- 7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine: B.L. Pope, et al.; Cancer Immunol. Immunother. 38, 83 (1994)
- The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines: B.L. Pope, et al.; Cell Immunol. 162, 333 (1995)
- Phase 1, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer: S.S. Agarwala, et al.; Cytokines Cell Mol. Ther. 6, 171 (2000)
- Recognition of pathogen-associated molecular patterns by TLR family: S. Akira & H. Hemmi; Immunol. Lett. 85, 85 (2003) (Review)
- The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily: F. Heil, et al.; Eur. J. Immunol. 33, 2987 (2003)
- Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8: K.B. Gorden, et al.; J. Immunol. 174,1259 (2005)
- Intervention of Toll-like receptor-mediated human innate immunity and inflammation by synthetic compounds and naturally occurring products: S. Fasciano & L. Li; Curr. Med. Chem. 13, 1389 (2006) (Review)
- Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides: M. Jurk, et al.; Eur. J. Immunol. 36, 1815 (2006)
- Autophagy-mediated anti-tumoral activity of imiquimod in Caco-2 cells: J.Y. Yi, et al.; BBRC 386, 455 (2009)
- Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability: T. Dzopalic, et al.; Int. Immunopharmacol. 10, 1428 (2010)
- Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain: I. Koji, et al.; Pain 158, 1538 (2017)
- TLR7 agonists display potent antiviral effects against norovirus infection via innate stimulation: D.E. Tuipulotu, et al.; Antimicrob. Agents Chemother. 62, e02417 (2018)
- Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat: H. Tabata, et al.; BMC Urology 21, 156 (2021)
- Analgesic Effect of the Kampo Formula Yokukansan via the Suppression of Substance P in an Experimental Rat Model of Hunner-Type Interstitial Cystitis: Y. Tsunokawa, et al.; Cureus 16, e52238 (2024)
Related Products
