FTY720 . hydrochloride

CHF 15.00
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Product Details
Synonyms 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl;
Fingolimod; Gilenya
Product Type Chemical
Properties
Formula

C19H33NO2 . HCl

MW 307.4 . 36.5
CAS 162359-56-0
RTECS TY3130000
Source/Host Chemicals Synthetic analog of ISP-1, isolated from Isaria sinclairii.
Purity Chemicals ≥98%
Appearance White solid.
Solubility Soluble in DMSO, ethanol or DMF.
InChi Key SWZTYAVBMYWFGS-UHFFFAOYSA-N
Smiles [Cl-].CCCCCCCCC1=CC=C(CCC([NH3+])(CO)CO)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis.
  • Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase.
  • Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer.
  • Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors.
  • Shown to induce autophagy and apoptosis.
Product References
  1. FTY720: Altered lymphocyte traffic results in allograft protection: V. Brinkmann, et al.; Transplantation 72, 764 (2001)
  2. The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002)
  3. FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes: S.M. Honig, et al.; J. Clin. Invest. 111, 627 (2003)
  4. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1: M. Matloubian, et al.; Nature 427, 355 (2004)
  5. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007)
  6. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite: C.R. Strader, et al.; J. Nat. Prod. 74, 900 (2011)
  7. Autophagy induced by FTY720 promotes apoptosis in U266 cells: A. Liao, et al.; Eur. J. Pharm. Sci. 45, 600 (2012)
  8. Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma: A. Estrada-Bernal, et al.; Neuro Oncol. 14, 405 (2012)
  9. T resident helper cells promote humoral responses in the lung: N. Swarnalekha, et al.; Sci. Immunol. 6, eabb6808 (2021) [in vivo application]
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