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AdipoGen Life Sciences
cGAMP . disodium salt
110
CHF
CHF 110.00
In stock
AG-CR1-3588-C100100 µgCHF 110.00
AG-CR1-3588-C500500 µgCHF 330.00
| Product Details | |
|---|---|
| Synonyms | cyclic (Adenosine monophosphate-guanosine monophosphate); cyclic GMP-AMP; c-(GpAp); c-(ApGp); 3',3'-cGAMP |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24N10O13P2 . 2Na |
| MW | 674.4 . 46.0 |
| CAS | 849214-04-6 (free acid) |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Crystalline solid. |
| Solubility | Soluble in water. |
| Reconstitution | Use sterile, endotoxin-free water (Prod. No. IAX-900-002). |
| Identity | Determined by ESI-MS, UV/Vis |
| InChi Key | MFPHQIYDBUVTRL-HBMYJXICSA-L |
| Smiles | [Na+].[Na+].NC1=NC2=C(N=CN2C2O[C@H]3CO[P@@]([O-])(=O)OC4C(COP([O-])(=O)OC3C2O)O[C@@H](C4O)N2C=NC3=C(N)N=CN=C23)C(=O)N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 6 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent STING ligand [2-8].
- Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA [2-4].
- Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-β [3-6].
- First cyclic nucleotide in metazoa [4].
- Plays a role in bacterial chemotaxis and colonization [1].
Product References
- Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence: B.W. Davies, et al.; Cell 149, 358 (2012)
- Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA: J. Wu, et al.; Science 339, 826 (2013)
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway: L. Sun, et al.; Science 339, 786 (2013)
- Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase: P. Gao, et al.; Cell 153, 1094 (2013)
- The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING: E.J. Diner, et al.; Cell Rep. 3, 1355 (2013)
- cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING: A. Ablasser, et al.; Nature 498, 380 (2013)
- Structural mechanism of cytosolic DNA sensing by cGAS: F. Civril, et al.; Nature 498, 332 (2013)
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING: X. Zhang, et al.; Mol. Cell 51, 226 (2013)
- The cGAS-STING Pathway for DNA Sensing: T.S. Xiao & K.A. Fitzgerald; Mol. Cell 51, 135 (2013)
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