β-Mannosylceramide

CHF 190.00
In stock
AG-CR1-3621-C250250 µgCHF 190.00
AG-CR1-3621-M0011 mgCHF 380.00
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Product Details
Synonyms β-ManCer; β-Mannosyl Ceramide; (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(β-D-mannopyranosyl)-1,3,4-octadecanetriol
Product Type Chemical
Properties
Formula C50H99NO9
MW 858.3
CAS 1334332-65-8
Purity Chemicals ≥95% (TLC, NMR)
Appearance White to off-white solid.
Solubility Soluble in pyridine or warm DMSO. Insoluble in water.
Identity Determined by 1H-NMR.
Other Product Data Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity. They express T cell receptors (TCR) on their surface consisting of an invariable α-chain and a somewhat variable β-chain. The majority of NKT cells express the invariable α-chain Vα14-Jα18 (Vα14) in mouse or its homolog in humans Vα24-Jα18 (Vα24). NKT cells expressing the invariant Vα19-Jα26 TCR α-chain (Vα19 NKT cells) have been found in peripheral blood lymphocytes and in the liver.
InChi Key VQFKFAKEUMHBLV-JDMIZZMOSA-N
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Aliquot into glass vials.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent stimulator of invariant natural killer T (iNKT) cells.
  • Induces strong antitumor immunity through a nitric oxide (NO) and TNF-α dependent mechansim, different compared to the IFN-γ dependent mechanism of α-GalCer (AG-CN2-0014).
  • Does not induce anergy of iNKT cells.
Product References
  1. Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity: J.J. O'Konek, et al.; J. Clin. Invest. 121, 683 (2011)
  2. NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma: S.R. Mattarollo, et al.; Blood 120, 3019 (2012)
  3. β-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy: J.J. O'Konek, et al.; Clin. Cancer Res. 19, 4404 (2013)
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