Regorafenib

CHF 35.00
In stock
AG-CR1-3623-M0055 mgCHF 35.00
AG-CR1-3623-M02525 mgCHF 80.00
More Information
Product Details
Synonyms BAY 73-4506; Fluoro-Sorafenib
Product Type Chemical
Properties
Formula

C21H15ClF4N4O3

MW 482.8
CAS 755037-03-7
Purity Chemicals ≥98% (HPLC)
Appearance Light pink to white solid.
Solubility Soluble in DMSO (>50mg/ml). Slightly soluble in ethanol (1mg/ml). Insoluble in water.
InChi Key FNHKPVJBJVTLMP-UHFFFAOYSA-N
Smiles CNC(=O)C1=CC(OC2=CC(F)=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=CC=N1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Orally bioavailable potent antitumor, antiangiogenic, antiproliferative and antineoplastic agent.
  • Multi-target kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively.
Product References
  1. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity: S.M. Wilhelm, et al.; Int. J. Cancer 129, 245 (2011)
  2. Differential properties of current tyrosine kinase inhibitors in gastrointestinal stromal tumors: G.D. Demetri; Semin. Oncol. 38, S10 (2011)
  3. Regorafenib: a guide to its use in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib and sunitinib: K.A. Lyseng-Williamson, et al.; BioDrugs 27, 525 (2013) (Review)
  4. Regorafenib: a novel multitargeted tyrosine kinase inhibitor for colorectal cancer and gastrointestinal stromal tumors: D.J. Crona, et al.; Ann. Pharmacother. 47, 1685 (2013) (Review)
  5. Regorafenib (BAY 73-4506): antitumor and antimetastatic activities in preclinical models of colorectal cancer: R. Schmieder, et al.; Int. J. Cancer 135, 1487 (2014)
  6. Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis: Z. Weng, et al.; Toxicology 327, 10 (2015)
  7. Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling: T. Goncharov, et al.; Mol. Cell. 69, 551 (2018)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.