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AdipoGen Life Sciences
CK2 Inhibitor 10
35
CHF
CHF 35.00
In stock
AG-CR1-3626-M0011 mgCHF 35.00
AG-CR1-3626-M0055 mgCHF 110.00
| Product Details | |
|---|---|
| Synonyms | CK2-VIII; 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H14N2O4S . 0.5H2O |
| MW | 354.4 . 9.0 |
| CAS | 1361229-76-6 |
| Purity Chemicals | ≥98% (HPLC, MS, NMR) |
| Appearance | Off-white to pale yellow solid. |
| Solubility | Soluble in DMSO. Insoluble in water. |
| InChi Key | UPIVZLFKYMNZDG-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2α=32nM and IC50 CK2α'=46nM).
- Potently also inhibits DYRK1B and FLT3.
- Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7.
- Promoted cAMP-induced thermogenesis in white adipocytes.
- CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
Product References
- Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds: Z. Hou, et al.; J. Med. Chem. 55, 2899 (2012)
- Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure: K. Shinoda, et al.; Cell Metab. 22, 997 (2015)